2-chloropentanoic acid

Base Information

• Chemical Name: 2-chloropentanoic acid
• CAS No.: 94347-45-2
• Molecular Formula: C₅H₉ClO₂
• Molecular Weight: 136.578
• Mol file: 94347-45-2.mol

Synonyms:2-chloropentanoic acid

Chemical Property of 2-chloropentanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloropentanoic acid

There total 12 articles about 2-chloropentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

D-norvaline (2013-12-9,498-18-0) → (2R)-2-Chloropentanoic acid (6155-96-0,32644-12-5,94347-45-2,80919-72-8)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; at 0 ℃;

DOI:10.1016/j.bmc.2013.11.030

Reference yield:

valeric acid (109-52-4) → 4-chloropentanoic acid (32607-54-8) + 2-chloropentanoic acid (94347-45-2) + 5-chloro-valeric acid (1119-46-6) + 2-chlorobutanecarboxylic acid (51637-47-9)

Guidance literature:

With chlorine; In neat (no solvent); Product distribution; Ambient temperature; liquid phase chlorination of the aliphatic C₅-carboxylic acids and their chlorides, methyl esters and chloromethyl esters, relative reactivity of each hydrogen atoms;

Reference yield:

Dimethyl-1-oxopentanphosphonat (55339-93-0) → 2-chloropentanoic acid (94347-45-2) + 2,2-dichloropentanoic acid (18240-68-1)

Guidance literature:

With hydrogenchloride; sodium hydroxide; sulfuryl dichloride; water; dihydrogen peroxide; sodium hydrogencarbonate; Yield given. Multistep reaction. Yields of byproduct given; 1.) rt, 7 h; 2.) rt, 16 h;

DOI:10.1016/S0040-4039(98)01939-X

upstream raw materials:

valeric acid

Dimethyl-1-oxopentanphosphonat

methyl rac-2-chloropentanoate

D-norvaline

Downstream raw materials:

(-)-(1'S,3S,6'R)-1-(2,2,6-trimethylcyclohexyl)hexan-3-ol

(+)-(1'R,3S,6'S)-1-(2,2,6-trimethylcyclohexyl)hexan-3-ol

(1'S,3S,6'S)-1-(2,2,6-trimethylcyclohexyl)hex-1-en-3-ol

(S)-1,2-epoxypentane

Refernces

• 1、 Plazinska, Anita,Pajak, Karolina,Rutkowska, Ewelina,Jimenez, Lucita,Kozocas, Joseph,Koolpe, Gary,Tanga, Mary,Toll, Lawrence,Wainer, Irving W.,Jozwiak, Krzysztof. "Comparative molecular field analysis of fenoterol derivatives interacting with an agonist-stabilized form of the β2-adrenergic receptor". . p. 234 - 246. Retrieved 2014/01/17.
• 2、 Margot, Christian,Simmons, Dana P.,Reichlin, Daniel,Skuy, David. "Amber-woody scent: Alcohols with divergent structure present common olfactory characteristics and sharp enantiomer differentiation". . p. 2662 - 2684. Retrieved 2007/10/03.