(1R)-7,8-Dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Base Information

Chemical Name:(1R)-7,8-Dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine
CAS No.:62717-90-2
Molecular Formula:C18H21NO2
Molecular Weight:283.37
Hs Code.:
DSSTox Substance ID:DTXSID40510911
Nikkaji Number:J355.409K
Wikidata:Q82369465

Synonyms:62717-90-2;SCHEMBL7621209;DTXSID40510911;(1R)-7,8-Dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Suppliers and Price of (1R)-7,8-Dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R)-7,8-Dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:283.157228913
Heavy Atom Count:21
Complexity:316

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(C=C2C(CNCCC2=C1)C3=CC=CC=C3)OC
Isomeric SMILES:COC1=C(C=C2[C@H](CNCCC2=C1)C3=CC=CC=C3)OC

Technology Process of (1R)-7,8-Dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

There total 5 articles about (1R)-7,8-Dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: C₂₅H₂₅NO₅S

: 62717-90-2
(1R)-(+)-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: C₂₅H₂₅NO₅S; With samarium diiodide; In tetrahydrofuran;

With borane-THF; In tetrahydrofuran;
DOI:10.1038/s41557-021-00746-7

Reference yield: 69.2%

: 81633-75-2
(R)-3-cyano-2,3,4,5-tetrahydro-7,8-dimethoxy-1-phenyl-1H-3-benzazepine

: 62717-90-2
(1R)-(+)-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: With hydrogenchloride; In acetic acid; for 24h; Heating;
DOI:10.1021/jm00348a017

Reference yield:

: 56030-50-3
(+)-(R)-1-phenyl-N-methyl-7,8-dimethoxy-1,2,4,5-tetrahydro-3H-benzazepine

: 62717-90-2
(1R)-(+)-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: With hydrogenchloride; bromocyane; acetic acid; Yield given. Multistep reaction; 1.) benzene, 55-60 deg C, 4 h, 2.) reflux, 24 h;
DOI:10.1021/jm00086a016