56030-50-3

Basic information

• Product Name: Trepipam
• Synonyms: Trepipam;[1R,(+)]-2,3,4,5-Tetrahydro-7,8-dimethoxy-3-methyl-1-phenyl-1H-3-benzazepine;Trepipam [inn]
• CAS NO: 56030-50-3
• Molecular Formula: C₁₉H₂₃NO₂
• Molecular Weight: 297.39
• Mol File: 56030-50-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 416.8°Cat760mmHg
• Flash Point: 137.5°C
• Appearance: /
• Density: 1.072g/cm³
• Vapor Pressure: 3.72E-07mmHg at 25°C
• Refractive Index: 1.555
• CAS DataBase Reference: Trepipam(CAS DataBase Reference)
• NIST Chemistry Reference: Trepipam(56030-50-3)
• EPA Substance Registry System: Trepipam(56030-50-3)

Safety Data

• Hazardous Substances Data: 56030-50-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C19H23NO2/c1-20-10-9-15-11-18(21-2)19(22-3)12-16(15)17(13-20)14-7-5-4-6-8-14/h4-8,11-12,17H,9-10,13H2,1-3H3/t17-/m1/s1

Upstream product

• 5703-21-9 3,4-dimethoxyphenylacetaldehyde 
• 127239-58-1 (+)-(S)-2-{t-butoxycarbonyl(methyl)amino}-1-phenylethanol 
• 65058-52-8 N-methyl (S)-2-hydroxy-2-phenylethylamine 
• 17199-29-0 (S)-Mandelic acid 
• 20569-49-7 7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine 
• 20012-08-2 1-phenyl-N-methyl-7,8-dimethoxy-1,2,4,5-tetrahydro-3H-benzazepine 

Downstream Products

• 139689-19-3 (+)-6-Br-APB hydrobromide 
• 139689-16-0 (R)-(+)-3-allyl-6-bromo-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine 
• 139689-08-0 (R)-(+)-3-allyl-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride 
• 139689-14-8 (R)-(+)-6-bromo-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine 
• 139689-12-6 (R)-(+)-3-allyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride 
• 81702-42-3 (+)-SKF 38393 hydrochloride 
• 62717-90-2 (1R)-(+)-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine 
• 81633-75-2 (R)-3-cyano-2,3,4,5-tetrahydro-7,8-dimethoxy-1-phenyl-1H-3-benzazepine 
• 62717-63-9 (R)-2,3,4,5-tetrahydro-7,8-dihydroxy-3-methyl-1-phenyl-1H-3-benzazepine hydrobromide 

Relevant articles and documents

Stereoisomeric probes for the D1 dopamine receptor: synthesis and characterization of R-(+) and S-(-) enantiomers of 3-allyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine and its 6-bromo analogue.

Substituted 1-phenyl-3-benzazepines (e.g., SKF 38393 and fenoldopam) exhibit stereoselectivity in moderately high-affinity binding to and partial agonist activation of D1 dopamine receptors. The 3-allyl (APB) and the 3-allyl-6-chloro (6-Cl-APB) analogues

ENANTIOSPECIFIC SYNTHESIS OF (+)-(R)-1-PHENYL-3-METHYL-1,2,4,5-TETRAHYDROBENZAZEPINE FROM (+)-(S)-N-METHYL-1-PHENYL ETHANOLAMINE (HALOSTACHINE) via ARENE CHROMIUM TRICARBONYL METHODOLOGY

Acid promoted cyclisation of homochiral (R)-N-(3,4-dimethoxyphenethyl) halostachine chromium tricarbonyl is stereospecific, proceeding with retention of configuration, to afford, after decomplexation, homochiral (+)-(R)-1-phenyl-3-methyl-1,2,4,5-tatrahydr