4-Oxazolecarboxylic acid, 4,5-dihydro-2-(4-methoxyphenyl)-4-methyl-5-oxo-, phenyl ester, (4S)-

Base Information

Chemical Name:4-Oxazolecarboxylic acid, 4,5-dihydro-2-(4-methoxyphenyl)-4-methyl-5-oxo-, phenyl ester, (4S)-
CAS No.:627877-80-9
Molecular Formula:C18H15NO5
Molecular Weight:325.321
Hs Code.:

Synonyms:

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Chemical Property of 4-Oxazolecarboxylic acid, 4,5-dihydro-2-(4-methoxyphenyl)-4-methyl-5-oxo-, phenyl ester, (4S)-

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Technology Process of 4-Oxazolecarboxylic acid, 4,5-dihydro-2-(4-methoxyphenyl)-4-methyl-5-oxo-, phenyl ester, (4S)-

There total 5 articles about 4-Oxazolecarboxylic acid, 4,5-dihydro-2-(4-methoxyphenyl)-4-methyl-5-oxo-, phenyl ester, (4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 627877-63-8
2-(4-methoxyphenyl)-4-methyloxazol-5-yl phenyl carbonate

: 627877-80-9
4-methyl-5-oxo-2-(4-methoxyphenyl)-4,5-dihydrooxazole-4-carboxylic acid phenyl ester

Guidance literature:: With 4-mesityl-6-methyl-3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine; In dichloromethane; at -30 ℃; for 16h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/jo200984n

Reference yield:

: 627877-63-8
2-(4-methoxyphenyl)-4-methyloxazol-5-yl phenyl carbonate

: 627877-80-9
4-methyl-5-oxo-2-(4-methoxyphenyl)-4,5-dihydrooxazole-4-carboxylic acid phenyl ester

: 4-methyl-5-oxo-2-(4-methoxyphenyl)-4,5-dihydrooxazole-4-carboxylic acid phenyl ester

Guidance literature:: With acetic acid (1R)-1-(4-dimethylaminopyridin-3-yl)-2,2,2-triphenylethyl ester; In tert-Amyl alcohol; at 0 ℃; for 12h; Title compound not separated from byproducts;
DOI:10.1021/ja037223k

Reference yield:

: 108462-96-0
DL-N-(4-methoxybenzoyl)alanine

: 627877-80-9
4-methyl-5-oxo-2-(4-methoxyphenyl)-4,5-dihydrooxazole-4-carboxylic acid phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Ac₂O / 0.5 h / 65 °C

2: 0.285 g / Et₃N / tetrahydrofuran / 0.5 h / 0 °C

3: (S)-4-Me₂N-3-[CH(OAc)CPh₃]pyridine / 2-methyl-butan-2-ol / 12 h / 0 °C

With acetic anhydride; triethylamine; acetic acid (1S)-1-(4-dimethylaminopyridin-3-yl)-2,2,2-triphenylethyl ester; In tetrahydrofuran; tert-Amyl alcohol; 3: Steglich rearrangement;
DOI:10.1021/ja056150x