NSC 11344

Base Information

• Chemical Name: NSC 11344
• CAS No.: 5416-12-6
• Molecular Formula: C10H12N2O3
• Molecular Weight: 208.217
• Hs Code.: 2924299090
• Mol file: 5416-12-6.mol

Synonyms:Acetamide, N-(2,6-dimethyl-3-nitrophenyl)-;N-(2,6-dimethyl-3-nitrophenyl)acetamide;

Chemical Property of NSC 11344

Chemical Property:

• Vapor Pressure: 3.41E-05mmHg at 25°C
• Melting Point: 165 °C(Solv: hexane (110-54-3); benzene (71-43-2))
• Boiling Point: 354.2°C at 760 mmHg
• PKA: 14.22±0.70(Predicted)
• Flash Point: 168°C
• PSA: 74.92000
• Density: 1.247g/cm³
• LogP: 2.76620
• Storage Temp.: -20°C Freezer
• Solubility.: Methanol

Purity/Quality:

95% ^*data from raw suppliers

N-Acetyl-3-nitro-2,6-dimethylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: NSC 11344 is a useful compound in the synthesis of furopyridinylaminoindazoles and imidazoles as Raf kinase inhibitors and in the synthesis of peptides, as hepatitis C virus inhibitors.

Technology Process of NSC 11344

There total 2 articles about NSC 11344 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

N-(2,6-dimethylphenyl)acetamide (2198-53-0) → N-(2,6-dimethyl-3-nitro-phenyl)acetamide (5416-12-6)

Guidance literature:

With sulfuric acid; nitric acid; acetic acid; at 0 - 20 ℃; for 1h;

Reference yield:

2,6-dimethylaniline (87-62-7) → N-(2,6-dimethyl-3-nitro-phenyl)acetamide (5416-12-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent

2: 80 percent / 65percent HNO₃ / acetic acid; H₂SO₄ / 1 h / Ambient temperature

With nitric acid; In sulfuric acid; acetic acid;

Reference yield: 99.0%

N-(2,6-dimethyl-3-nitro-phenyl)acetamide (5416-12-6) → 2,6-dimethyl-3-nitroaniline (67083-28-7)

Guidance literature:

With hydrogenchloride; In methanol; for 48h; Heating / reflux;

upstream raw materials:

N-(2,6-dimethylphenyl)acetamide

2,6-dimethylaniline

Downstream raw materials:

2,6-dimethyl-3-nitroaniline

3-bromo-2,6-dimethylacetanilide

N-(3-hydroxy-2,6-dimethylphenyl)acetamide

3-amino-2,4-dimethyl-phenol