(4-Fluorophenyl)(3-hydroxyphenyl)methanone

Base Information

• Chemical Name: (4-Fluorophenyl)(3-hydroxyphenyl)methanone
• CAS No.: 62810-47-3
• Molecular Formula: C13H9FO2
• Molecular Weight: 216.20800
• DSSTox Substance ID: DTXSID80505306
• Nikkaji Number: J772.150A
• Wikidata: Q82360315

Synonyms:(4-Fluorophenyl)(3-hydroxyphenyl)methanone;62810-47-3;Methanone, (4-fluorophenyl)(3-hydroxyphenyl)-;(4-fluorophenyl)-(3-hydroxyphenyl)methanone;SCHEMBL9468468;4'-fluoro-3-hydroxybenzophenone;DTXSID80505306;MFCD16309309;SY268390;CS-0120961;E87055

Chemical Property of (4-Fluorophenyl)(3-hydroxyphenyl)methanone

Chemical Property:

• Melting Point: 105°C
• Boiling Point: 380.6±27.0 °C(Predicted)
• PSA: 37.30000
• Density: 1.270±0.06 g/cm3(Predicted)
• LogP: 2.76230
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 216.05865769
• Heavy Atom Count: 16
• Complexity: 246

Purity/Quality:

99% ^*data from raw suppliers

(4-Fluorophenyl)(3-hydroxyphenyl)methanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)O)C(=O)C2=CC=C(C=C2)F

Technology Process of (4-Fluorophenyl)(3-hydroxyphenyl)methanone

There total 2 articles about (4-Fluorophenyl)(3-hydroxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

fluorobenzene (462-06-6) + m-anisoyl chloride (1711-05-3) → (4-Fluoro-phenyl)-(3-hydroxy-phenyl)-methanone (62810-47-3)

Guidance literature:

With aluminium trichloride; 1.) room temp., 1.5 h, 2.) reflux, 2 h;

Reference yield:

fluorobenzene (462-06-6) + m-nitrobenzoic acid chloride (121-90-4) → (4-Fluoro-phenyl)-(3-hydroxy-phenyl)-methanone (62810-47-3)

Guidance literature:

Multistep reaction;

Reference yield: 81.0%

(4-Fluoro-phenyl)-(3-hydroxy-phenyl)-methanone (62810-47-3) + Ethyl 2-bromopropionate (535-11-5,41978-69-2) → 2-[3-(4-Fluoro-benzoyl)-phenoxy]-propionic acid ethyl ester (74167-95-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 4h;

upstream raw materials:

fluorobenzene

m-nitrobenzoic acid chloride

m-anisoyl chloride

Downstream raw materials:

2-[3-(4-Fluoro-benzoyl)-phenoxy]-propionic acid ethyl ester

(4-fluoro-phenyl)-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-methanone

2-[3-(4-Fluoro-benzoyl)-phenoxy]-propionic acid

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