3-(2-Methoxyphenyl)prop-2-ynoyl chloride

Base Information

Chemical Name:3-(2-Methoxyphenyl)prop-2-ynoyl chloride
CAS No.:62848-99-1
Molecular Formula:C₁₀H₇ClO₂
Molecular Weight:194.617
Hs Code.:
DSSTox Substance ID:DTXSID70562761
Wikidata:Q82447032

Synonyms:3-(2-Methoxyphenyl)prop-2-ynoyl chloride;62848-99-1;DTXSID70562761

Suppliers and Price of 3-(2-Methoxyphenyl)prop-2-ynoyl chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(2-Methoxyphenyl)prop-2-ynoyl chloride

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:194.0134572
Heavy Atom Count:13
Complexity:248

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=CC=C1C#CC(=O)Cl

Technology Process of 3-(2-Methoxyphenyl)prop-2-ynoyl chloride

There total 4 articles about 3-(2-Methoxyphenyl)prop-2-ynoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7342-00-9
3-(2-methoxyphenyl)prop-2-ynoic acid

: 62848-99-1
(2-methoxy-phenyl)-propioloyl chloride

Guidance literature:: With sodium hydroxide; thionyl chloride; Yield given. Multistep reaction; 2) ether, reflux, 6 h;
DOI:10.1039/P19940002461

Reference yield:

: 80220-94-6
ethyl 3-(2-methoxyphenyl)prop-2-ynoate

: 62848-99-1
(2-methoxy-phenyl)-propioloyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: NaOH, benzyltriethylammonium chloride / H₂O; diethyl ether / 120 h

2: 1.) aq. NaOH, 2.) SOCl₂ / 2) ether, reflux, 6 h

With sodium hydroxide; thionyl chloride; N-benzyl-N,N,N-triethylammonium chloride; In diethyl ether; water;
DOI:10.1039/P19940002461

Reference yield:

: 529-28-2
4-iodoanisol

: 62848-99-1
(2-methoxy-phenyl)-propioloyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C

1.2: 9 h / -78 - 20 °C

1.3: 50 °C / Inert atmosphere

2.1: water; potassium hydroxide / methanol / 12 h / 25 °C

3.1: thionyl chloride / 8 h / 25 °C / neat (no solvent)

With thionyl chloride; water; potassium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; 1.3: Negishi cross-coupling reaction;
DOI:10.1055/s-0030-1258399