1-Benzyl-4-phenylpiperidine-4-methanol

Base Information

• Chemical Name: 1-Benzyl-4-phenylpiperidine-4-methanol
• CAS No.: 59083-36-2
• Molecular Formula: C19H23 N O
• Molecular Weight: 281.398
• European Community (EC) Number: 261-592-6
• NSC Number: 89589
• DSSTox Substance ID: DTXSID80207818
• Nikkaji Number: J308.610K
• Wikidata: Q83081814
• ChEMBL ID: CHEMBL59910
• Mol file: 59083-36-2.mol

Synonyms:1-Benzyl-4-phenylpiperidine-4-methanol;59083-36-2;EINECS 261-592-6;NSC89589;CHEMBL59910;SCHEMBL2789160;DTXSID80207818;NSC 89589;NSC-89589;4-Phenyl-1-(phenylmethyl)-4-piperidinemethanol

Chemical Property of 1-Benzyl-4-phenylpiperidine-4-methanol

Chemical Property:

• Vapor Pressure: 1.3E-07mmHg at 25°C
• Boiling Point: 414.5°C at 760 mmHg
• Flash Point: 195.6°C
• PSA: 23.47000
• Density: 1.094g/cm³
• LogP: 3.15060
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 281.177964357
• Heavy Atom Count: 21
• Complexity: 297

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCC1(CO)C2=CC=CC=C2)CC3=CC=CC=C3

Technology Process of 1-Benzyl-4-phenylpiperidine-4-methanol

There total 2 articles about 1-Benzyl-4-phenylpiperidine-4-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-phenyl-piperidine-4-carboxylic acid (3627-45-0) + benzyl bromide (100-39-0) → 1-benzyl-4-(hydroxymethyl)-4-phenylpiperidine (59083-36-2) + 4-(hydroxymethyl)-4-phenylpiperidine hydrochloride (15247-00-4)

Guidance literature:

With hydrogenchloride; sodium hydroxide; borane; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; acetone;

Reference yield:

→ 1-benzyl-4-(hydroxymethyl)-4-phenylpiperidine (59083-36-2)

Guidance literature:

entspr. 4-Carbonsaeure-ester, LiAlH4;

DOI:10.1135/cccc19753904

Reference yield: 45.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1-benzyl-4-(hydroxymethyl)-4-phenylpiperidine (59083-36-2) → 1'-benzylspiro hydrochloride (75930-61-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 10h; Heating;

DOI:10.1248/cpb.29.402

upstream raw materials:

4-phenyl-piperidine-4-carboxylic acid

benzyl bromide

Downstream raw materials:

1'-benzylspiro hydrochloride

1'-benzylspiro-1-one

1'-benzylspiro-1-one hydrochloride

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