Cyclohexanone, 3-[(1R)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-methylethyl]-6-methyl-2 -[2-methyl-3-oxo-4-(phenylmethoxy)butyl]-, (3R,6S)-

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Chemical Name:Cyclohexanone, 3-[(1R)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-methylethyl]-6-methyl-2 -[2-methyl-3-oxo-4-(phenylmethoxy)butyl]-, (3R,6S)-
CAS No.:629618-18-4
Molecular Formula:C38H50O4Si
Molecular Weight:598.898
Hs Code.:

Cyclohexanone,
3-[(1R)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-methylethyl]-6-methyl-2
-[2-methyl-3-oxo-4-(phenylmethoxy)butyl]-, (3R,6S)-

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Chemical Property of Cyclohexanone, 3-[(1R)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-methylethyl]-6-methyl-2 -[2-methyl-3-oxo-4-(phenylmethoxy)butyl]-, (3R,6S)-

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Technology Process of Cyclohexanone, 3-[(1R)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-methylethyl]-6-methyl-2 -[2-methyl-3-oxo-4-(phenylmethoxy)butyl]-, (3R,6S)-

There total 3 articles about Cyclohexanone, 3-[(1R)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-methylethyl]-6-methyl-2 -[2-methyl-3-oxo-4-(phenylmethoxy)butyl]-, (3R,6S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 103791-04-4
Benzyloxymethyl isopropenyl ketone

: 629618-17-3
(2S,5S)-5-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2-methyl-cyclohexanone

: 629618-18-4
(3R,6S)-2-(4-Benzyloxy-2-methyl-3-oxo-butyl)-3-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-6-methyl-cyclohexanone

Guidance literature:: (2S,5S)-5-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2-methyl-cyclohexanone; With chloro-trimethyl-silane; lithium diisopropyl amide; In 1,2-dimethoxyethane; at -60 ℃; for 0.166667h;

Benzyloxymethyl isopropenyl ketone; With tin(IV) chloride; In dichloromethane; at -78 ℃; for 4h;
DOI:10.1021/ja0378916

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 629618-18-4
(3R,6S)-2-(4-Benzyloxy-2-methyl-3-oxo-butyl)-3-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-6-methyl-cyclohexanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: 96 percent / imidazole / dimethylformamide / 23 °C

2.1: LDA; TMSCl / 1,2-dimethoxy-ethane / 0.17 h / -60 °C

2.2: 61 percent / SnCl₄ / CH₂Cl₂ / 4 h / -78 °C

With 1H-imidazole; chloro-trimethyl-silane; lithium diisopropyl amide; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;
DOI:10.1021/ja0378916

Reference yield:

: 122999-66-0
2-methyl-5-[2-hydroxy-1-methylethyl]cyclohexanone

: 629618-18-4
(3R,6S)-2-(4-Benzyloxy-2-methyl-3-oxo-butyl)-3-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-6-methyl-cyclohexanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: 96 percent / imidazole / dimethylformamide / 23 °C

2.1: LDA; TMSCl / 1,2-dimethoxy-ethane / 0.17 h / -60 °C

2.2: 61 percent / SnCl₄ / CH₂Cl₂ / 4 h / -78 °C

With 1H-imidazole; chloro-trimethyl-silane; lithium diisopropyl amide; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;
DOI:10.1021/ja0378916