122999-66-0

Downstream Products

• 629618-23-1 6-[2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4,9-dimethyl-6,7,8,9-tetrahydro-3H-1-oxa-3-aza-cyclopenta[a]naphthalen-2-one 
• 630110-07-5 (5R,8S)-1-Benzyloxy-5-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-8a-hydroxy-3,8-dimethyl-octahydro-naphthalen-2-one 
• 629618-32-2 N-{5-[2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-1-hydroxy-3,8-dimethyl-5,6,7,8-tetrahydro-naphthalen-2-yl}-acetamide 
• 629618-19-5 1-benzyloxy-5-[2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-3,8-dimethyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one 
• 629618-18-4 (3R,6S)-2-(4-Benzyloxy-2-methyl-3-oxo-butyl)-3-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-6-methyl-cyclohexanone 
• 629618-27-5 Methanesulfonic acid (5R,8S)-2-acetylamino-5-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-3,8-dimethyl-5,6,7,8-tetrahydro-naphthalen-1-yl ester 
• 629618-22-0 N-{1-benzyloxy-5-[2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-3,8-dimethyl-5,6,7,8-tetrahydro-naphthalen-2-yl}-acetamide 
• 219498-10-9 (3R,6S)-2-(4-Benzyloxy-2-methyl-3-oxo-butyl)-3-((E)-(S)-1,5-dimethyl-hexa-2,4-dienyl)-6-methyl-cyclohexanone 
• 219566-61-7 (5R,8S)-1-Benzyloxy-5-((E)-(S)-1,5-dimethyl-hexa-2,4-dienyl)-8a-hydroxy-3,8-dimethyl-octahydro-naphthalen-2-one 
• 219498-11-0 (5R,8S)-1-Benzyloxy-5-((E)-(S)-1,5-dimethyl-hexa-2,4-dienyl)-3,8-dimethyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one 
• 219498-08-5 [(3R,6S)-3-((E)-(S)-1,5-Dimethyl-hexa-2,4-dienyl)-6-methyl-cyclohex-1-enyloxy]-trimethyl-silane 
• 219498-05-2 (2S,5S)-5-((E)-(R)-1,5-Dimethyl-hexa-2,4-dienyl)-2-methyl-cyclohexanone 
• 219497-98-0 (1S,4S,8R)-(-)-menthane-2,9-dione 

Relevant academic research and scientific papers

A direct and efficient stereocontrolled synthetic route to the pseudopterosins, potent marine antiinflammatory agents

Described herein is a new synthetic route to pseudopterosin aglycone (3), a key intermediate for the synthesis of a group of antiinflammatory natural products including pseudopterosin A (1) and E (2). The pathway of synthesis starts with the abundant and inexpensive (S)-(-)-limonene and its long-known cyclic hydroboration product (4) and leads to the chiral hydroxy ketone 6. Conversion of 6 to 10 followed by a novel aromatic annulation produced 15 which underwent a highly diastereoselective cyclization to afford the protected pseudopterosin aglycone 16. The naturally occurring pseudopterosins such as 1 and 2 are readily available from this key intermediate.