QUINOLIN-7-YLBORONIC ACID

Base Information

• Chemical Name: QUINOLIN-7-YLBORONIC ACID
• CAS No.: 629644-82-2
• Molecular Formula: C9H8BNO2
• Molecular Weight: 172.979
• Hs Code.: 2933499090
• Mol file: 629644-82-2.mol

Synonyms:quinolin-7-ylboronic acid;

Chemical Property of QUINOLIN-7-YLBORONIC ACID

Chemical Property:

• Boiling Point: 400.3±37.0 °C(Predicted)
• PKA: 7.43±0.30(Predicted)
• PSA: 53.35000
• Density: 1.28
• LogP: -0.08540
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Quinoline-7-boronic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of QUINOLIN-7-YLBORONIC ACID

There total 1 articles about QUINOLIN-7-YLBORONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-iodoquinoline (25334-12-7) → quinolin-7-yl-boronic acid (629644-82-2)

Guidance literature:

7-iodoquinoline; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.666667h;

With Trimethyl borate; In tetrahydrofuran; at -78 - 20 ℃; for 4h;

With hydrogenchloride; n-butyllithium; water; more than 3 stages;

Reference yield: 86.0%

quinolin-7-yl-boronic acid (629644-82-2) + methyl 4-((N-(4-bromophenyl)morpholine-4-carboxamido)methyl)benzoate → methyl 4-((N-(4-(quinolin-7-yl)phenyl)morpholine-4-carboxamido)methyl)benzoate

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In 1,4-dioxane; water; at 100 ℃; for 6h;

Reference yield: 72.7%

quinolin-7-yl-boronic acid (629644-82-2) + 2-chloro-3-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)pyridine → 7-(3-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)pyridin-2-yl)quinoline

Guidance literature:

With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium carbonate; In tetrahydrofuran; at 65 ℃; for 18h; Sealed tube; Inert atmosphere;

DOI:10.1002/cmdc.201900088

upstream raw materials:

7-iodoquinoline

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