Butanoic acid, 4-[[[(1S,2S)-2-[bis[(1,1-dimethylethoxy)carbonyl]amino]cyclopropyl]carb onyl]dioxy]-4-oxo-2-[[(phenylmethoxy)carbonyl]amino]-, methyl ester, (2S)-

Base Information

Chemical Name:Butanoic acid, 4-[[[(1S,2S)-2-[bis[(1,1-dimethylethoxy)carbonyl]amino]cyclopropyl]carb onyl]dioxy]-4-oxo-2-[[(phenylmethoxy)carbonyl]amino]-, methyl ester, (2S)-
CAS No.:629657-17-6
Molecular Formula:C27H36N2O12
Molecular Weight:580.589
Hs Code.:

Butanoic acid,
4-[[[(1S,2S)-2-[bis[(1,1-dimethylethoxy)carbonyl]amino]cyclopropyl]carb
onyl]dioxy]-4-oxo-2-[[(phenylmethoxy)carbonyl]amino]-, methyl ester,
(2S)-

Synonyms:

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Chemical Property of Butanoic acid, 4-[[[(1S,2S)-2-[bis[(1,1-dimethylethoxy)carbonyl]amino]cyclopropyl]carb onyl]dioxy]-4-oxo-2-[[(phenylmethoxy)carbonyl]amino]-, methyl ester, (2S)-

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Technology Process of Butanoic acid, 4-[[[(1S,2S)-2-[bis[(1,1-dimethylethoxy)carbonyl]amino]cyclopropyl]carb onyl]dioxy]-4-oxo-2-[[(phenylmethoxy)carbonyl]amino]-, methyl ester, (2S)-

There total 4 articles about Butanoic acid, 4-[[[(1S,2S)-2-[bis[(1,1-dimethylethoxy)carbonyl]amino]cyclopropyl]carb onyl]dioxy]-4-oxo-2-[[(phenylmethoxy)carbonyl]amino]-, methyl ester, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 629657-16-5
(1S,2S)-2-[bis(tert-butoxycarbonyl)amino]cyclopropane-1-carboxylic acid

: 629656-84-4
(2S)-2-benzyloxycarbonylamino-3-hydroperoxycarbonyl-propionic acid methyl ester

: 629657-17-6
(2S)-4-{(1S,2S)-2-[bis(tert-butoxycarbonyl)amino]cyclopropane-1-carbonylperoxy}-2-benzyloxycarbonylamino-4-oxo-butyric acid methyl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; at -40 - 0 ℃; for 0.833333h;
DOI:10.1021/ol035859a

Reference yield:

: 4668-42-2
(S)-2-benzyloxycarbonylamino-succinic acid 1-methyl ester

: 629657-17-6
(2S)-4-{(1S,2S)-2-[bis(tert-butoxycarbonyl)amino]cyclopropane-1-carbonylperoxy}-2-benzyloxycarbonylamino-4-oxo-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / DCC; DMAP / CH₂Cl₂ / 4 h / -40 - 20 °C

2: aqueous TFA / CHCl₃ / 0.25 h / 20 °C

3: 83 percent / DCC / CH₂Cl₂ / 0.83 h / -40 - 0 °C

With dmap; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; chloroform;
DOI:10.1021/ol035859a

Reference yield:

: 629657-13-2
(S,S)-[2-[bis(tert-butoxycarbonyl)amino]cyclopropyl]methanol

: 629657-17-6
(2S)-4-{(1S,2S)-2-[bis(tert-butoxycarbonyl)amino]cyclopropane-1-carbonylperoxy}-2-benzyloxycarbonylamino-4-oxo-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / NaIO₄; RuCl₃; NaHCO₃ / H₂O; acetonitrile; CHCl₃ / 2 h / 20 °C

2: 83 percent / DCC / CH₂Cl₂ / 0.83 h / -40 - 0 °C

With ruthenium trichloride; sodium periodate; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In dichloromethane; chloroform; water; acetonitrile;
DOI:10.1021/ol035859a