2(1H)-Naphthalenone, 5-[(1R)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-methylethyl]octahydro- 8a-hydroxy-3,8-dimethyl-1-(phenylmethoxy)-, (5R,8S)-

Base Information

Chemical Name:2(1H)-Naphthalenone, 5-[(1R)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-methylethyl]octahydro- 8a-hydroxy-3,8-dimethyl-1-(phenylmethoxy)-, (5R,8S)-
CAS No.:630110-07-5
Molecular Formula:C38H50O4Si
Molecular Weight:598.898
Hs Code.:

2(1H)-Naphthalenone,
5-[(1R)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-methylethyl]octahydro-
8a-hydroxy-3,8-dimethyl-1-(phenylmethoxy)-, (5R,8S)-

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Chemical Property of 2(1H)-Naphthalenone, 5-[(1R)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-methylethyl]octahydro- 8a-hydroxy-3,8-dimethyl-1-(phenylmethoxy)-, (5R,8S)-

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Technology Process of 2(1H)-Naphthalenone, 5-[(1R)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-methylethyl]octahydro- 8a-hydroxy-3,8-dimethyl-1-(phenylmethoxy)-, (5R,8S)-

There total 4 articles about 2(1H)-Naphthalenone, 5-[(1R)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-methylethyl]octahydro- 8a-hydroxy-3,8-dimethyl-1-(phenylmethoxy)-, (5R,8S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103791-04-4
Benzyloxymethyl isopropenyl ketone

: 630110-07-5
(5R,8S)-1-Benzyloxy-5-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-8a-hydroxy-3,8-dimethyl-octahydro-naphthalen-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA; TMSCl / 1,2-dimethoxy-ethane / 0.17 h / -60 °C

1.2: 61 percent / SnCl₄ / CH₂Cl₂ / 4 h / -78 °C

2.1: 83 percent / KOH / ethanol / 3 h / -10 °C

With potassium hydroxide; chloro-trimethyl-silane; lithium diisopropyl amide; In 1,2-dimethoxyethane; ethanol;
DOI:10.1021/ja0378916

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 630110-07-5
(5R,8S)-1-Benzyloxy-5-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-8a-hydroxy-3,8-dimethyl-octahydro-naphthalen-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 96 percent / imidazole / dimethylformamide / 23 °C

2.1: LDA; TMSCl / 1,2-dimethoxy-ethane / 0.17 h / -60 °C

2.2: 61 percent / SnCl₄ / CH₂Cl₂ / 4 h / -78 °C

3.1: 83 percent / KOH / ethanol / 3 h / -10 °C

With 1H-imidazole; potassium hydroxide; chloro-trimethyl-silane; lithium diisopropyl amide; In 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/ja0378916

Reference yield:

: 122999-66-0
2-methyl-5-[2-hydroxy-1-methylethyl]cyclohexanone

: 630110-07-5
(5R,8S)-1-Benzyloxy-5-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-8a-hydroxy-3,8-dimethyl-octahydro-naphthalen-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 96 percent / imidazole / dimethylformamide / 23 °C

2.1: LDA; TMSCl / 1,2-dimethoxy-ethane / 0.17 h / -60 °C

2.2: 61 percent / SnCl₄ / CH₂Cl₂ / 4 h / -78 °C

3.1: 83 percent / KOH / ethanol / 3 h / -10 °C

With 1H-imidazole; potassium hydroxide; chloro-trimethyl-silane; lithium diisopropyl amide; In 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/ja0378916