N-(3-Methylphenyl)-2-(4-phenylpiperidin-1-YL)acetamide

Base Information

• Chemical Name: N-(3-Methylphenyl)-2-(4-phenylpiperidin-1-YL)acetamide
• CAS No.: 630118-64-8
• Molecular Formula: C20H24N2O
• Molecular Weight: 308.41700
• ChEMBL ID: CHEMBL216393
• DSSTox Substance ID: DTXSID50582422
• Pharos Ligand ID: 8N4WSBT44GUM
• Wikidata: Q82473843
• Mol file: 630118-64-8.mol

Synonyms:CHEMBL216393;2-(4-phenylpiperidin-1-yl)-N-(m-tolyl)acetamide;SCHEMBL4006168;DTXSID50582422;N-(3-METHYLPHENYL)-2-(4-PHENYLPIPERIDIN-1-YL)ACETAMIDE;BDBM50200045

Chemical Property of N-(3-Methylphenyl)-2-(4-phenylpiperidin-1-YL)acetamide

Chemical Property:

• PSA: 35.83000
• LogP: 4.40050
• XLogP3: 4.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 308.188863393
• Heavy Atom Count: 23
• Complexity: 370

Purity/Quality:

A-412997 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CC=C1)NC(=O)CN2CCC(CC2)C3=CC=CC=C3
• Uses: The dopamine receptors play important role in cognition, memory, learning, and motor control (1). These receptors have been implicated as a therapeutic target for many psychiatric and neurological disorders. A-412997 Dihydrochloride is a selective agonist of the dopamine D4 receptor (2).

Technology Process of N-(3-Methylphenyl)-2-(4-phenylpiperidin-1-YL)acetamide

There total 6 articles about N-(3-Methylphenyl)-2-(4-phenylpiperidin-1-YL)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-phenylpiperidine (771-99-3) + 2-bromo-N-(3-methylphenyl)acetamide (5439-17-8) → 2-(4-phenylpiperidin-1-yl)-N-(m-tolyl)acetamide (630118-64-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

DOI:10.1021/jm060662k

Reference yield: 99.0%

4-phenylpiperidine (771-99-3) → 2-(4-phenylpiperidin-1-yl)-N-(m-tolyl)acetamide (630118-64-8)

Guidance literature:

Reference yield: 99.0%

→ 2-(4-phenylpiperidin-1-yl)-N-(m-tolyl)acetamide (630118-64-8)

Guidance literature:

upstream raw materials:

4-phenylpiperidine

2-bromo-N-(3-methylphenyl)acetamide

1-amino-3-methylbenzene

2-chloro-N-(3-methylphenyl)acetamide