2-Propenamide, N-[(1S,2S)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-(2-furanyl)-1-methyl ethyl]-N-(phenylmethyl)-

Base Information

Chemical Name:2-Propenamide, N-[(1S,2S)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-(2-furanyl)-1-methyl ethyl]-N-(phenylmethyl)-
CAS No.:630129-13-4
Molecular Formula:C₂₃H₃₃NO₃Si
Molecular Weight:399.605
Hs Code.:

Synonyms:

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Chemical Property of 2-Propenamide, N-[(1S,2S)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-(2-furanyl)-1-methyl ethyl]-N-(phenylmethyl)-

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Technology Process of 2-Propenamide, N-[(1S,2S)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-(2-furanyl)-1-methyl ethyl]-N-(phenylmethyl)-

There total 6 articles about 2-Propenamide, N-[(1S,2S)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-(2-furanyl)-1-methyl ethyl]-N-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-01-1
furfural

: 630129-13-4
(1S,2S)-2-N-acryloyl-2-N-benzyl-1-(2'-furyl)-1-O-(tert-butyldimethylsilyl)propane

Guidance literature:: Multi-step reaction with 6 steps

1.1: (R)-oxynitrilase (E_.⁽¹⁾C₄₂₁₀) / various solvent(s) / 4 °C / pH 5.5

2.1: imidazole / dimethylformamide / 0.25 h / 0 °C

2.2: 88 percent / dimethylformamide / 0 - 20 °C

3.1: diethyl ether / 1 h / Heating

3.2: diethyl ether; methanol / -70 - -20 °C

4.1: diethyl ether; methanol / -70 - -20 °C

5.1: 3.1 g / NaBH₄ / diethyl ether; methanol / -70 - 20 °C

6.1: 3.2 g / aq. Na₂CO₃ / CH₂Cl₂

With 1H-imidazole; sodium tetrahydroborate; (R)-oxynitrilase (E_.⁽¹⁾C₄₂₁₀); sodium carbonate; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 3.1: Grignard reaction;
DOI:10.1039/b307275d

Reference yield:

: 10017-07-9
(S)-2-(2'-furyl)-2-hydroxy-acetonitrile

: 630129-13-4
(1S,2S)-2-N-acryloyl-2-N-benzyl-1-(2'-furyl)-1-O-(tert-butyldimethylsilyl)propane

Guidance literature:: Multi-step reaction with 5 steps

1.1: imidazole / dimethylformamide / 0.25 h / 0 °C

1.2: 88 percent / dimethylformamide / 0 - 20 °C

2.1: diethyl ether / 1 h / Heating

2.2: diethyl ether; methanol / -70 - -20 °C

3.1: diethyl ether; methanol / -70 - -20 °C

4.1: 3.1 g / NaBH₄ / diethyl ether; methanol / -70 - 20 °C

5.1: 3.2 g / aq. Na₂CO₃ / CH₂Cl₂

With 1H-imidazole; sodium tetrahydroborate; sodium carbonate; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 2.1: Grignard reaction;
DOI:10.1039/b307275d

Reference yield:

: 139765-20-1
(S)-2-(tert-butyldimethylsilyloxy)-2-(furan-2-yl)acetonitrile

: 630129-13-4
(1S,2S)-2-N-acryloyl-2-N-benzyl-1-(2'-furyl)-1-O-(tert-butyldimethylsilyl)propane

Guidance literature:: Multi-step reaction with 4 steps

1.1: diethyl ether / 1 h / Heating

1.2: diethyl ether; methanol / -70 - -20 °C

2.1: diethyl ether; methanol / -70 - -20 °C

3.1: 3.1 g / NaBH₄ / diethyl ether; methanol / -70 - 20 °C

4.1: 3.2 g / aq. Na₂CO₃ / CH₂Cl₂

With sodium tetrahydroborate; sodium carbonate; In methanol; diethyl ether; dichloromethane; 1.1: Grignard reaction;
DOI:10.1039/b307275d