14-Oxa-2,6,12-triazahexadecanoic acid, 7-(carboxymethyl)-15,15-dimethyl-4-(2-methylpropyl)-5,13-dioxo-, 1-(phenylmethyl) ester, (4S,7S)-

Base Information

Chemical Name:14-Oxa-2,6,12-triazahexadecanoic acid, 7-(carboxymethyl)-15,15-dimethyl-4-(2-methylpropyl)-5,13-dioxo-, 1-(phenylmethyl) ester, (4S,7S)-
CAS No.:631899-27-9
Molecular Formula:C27H43N3O7
Molecular Weight:521.654
Hs Code.:

Synonyms:

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Chemical Property of 14-Oxa-2,6,12-triazahexadecanoic acid, 7-(carboxymethyl)-15,15-dimethyl-4-(2-methylpropyl)-5,13-dioxo-, 1-(phenylmethyl) ester, (4S,7S)-

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Technology Process of 14-Oxa-2,6,12-triazahexadecanoic acid, 7-(carboxymethyl)-15,15-dimethyl-4-(2-methylpropyl)-5,13-dioxo-, 1-(phenylmethyl) ester, (4S,7S)-

There total 5 articles about 14-Oxa-2,6,12-triazahexadecanoic acid, 7-(carboxymethyl)-15,15-dimethyl-4-(2-methylpropyl)-5,13-dioxo-, 1-(phenylmethyl) ester, (4S,7S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 631899-26-8
Cbz-(S)-β²-HLeu-(S)-β³-HLys(Boc)-OMe

: 631899-27-9
Cbz-(S)-β²-HLeu-(S)-β³-HLys(Boc)-OH

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 0 ℃; for 20h;
DOI:10.1002/hlca.200390133

Reference yield:

: 2389-60-8
Z-Lys(Boc)-OH

: 631899-27-9
Cbz-(S)-β²-HLeu-(S)-β³-HLys(Boc)-OH

Guidance literature:: Multi-step reaction with 5 steps

1.1: Et₃N; i-BuOCOCl / tetrahydrofuran / 0.5 h / -25 °C

1.2: 74 percent / tetrahydrofuran; diethyl ether / 16 h

2.1: 80 percent / silver benzoate; Et₃N / 5 h / -25 - 20 °C

3.1: 98 percent / H₂ / Pd/C / methanol / 16 h / 750.06 Torr

4.1: NMM; NMM*TFA / CHCl₃ / 0.25 h / 0 °C

4.2: HOBt / CHCl₃ / 0.25 h

4.3: 869 mg / EDC / CHCl₃ / 24 h / 0 °C

5.1: 100 percent / LiOH*H₂O / tetrahydrofuran; H₂O / 20 h / 0 °C

With 4-methyl-morpholine; lithium hydroxide; NMM*TFA; hydrogen; silver benzoate; triethylamine; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; water;
DOI:10.1002/hlca.200390133

Reference yield:

: 114479-97-9
(S)-3-{[(benzyloxy)carbonyl]amino}-7-{[(tert-butoxy)carbonyl]amino}-1-diazoheptan-2-one

: 631899-27-9
Cbz-(S)-β²-HLeu-(S)-β³-HLys(Boc)-OH

Guidance literature:: Multi-step reaction with 4 steps

1.1: 80 percent / silver benzoate; Et₃N / 5 h / -25 - 20 °C

2.1: 98 percent / H₂ / Pd/C / methanol / 16 h / 750.06 Torr

3.1: NMM; NMM*TFA / CHCl₃ / 0.25 h / 0 °C

3.2: HOBt / CHCl₃ / 0.25 h

3.3: 869 mg / EDC / CHCl₃ / 24 h / 0 °C

4.1: 100 percent / LiOH*H₂O / tetrahydrofuran; H₂O / 20 h / 0 °C

With 4-methyl-morpholine; lithium hydroxide; NMM*TFA; hydrogen; silver benzoate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; water;
DOI:10.1002/hlca.200390133