Hexanoic acid, 6-[[[[4-amino-3'-[[5-[[[(1,1-dimethylethoxy)carbonyl]amino]iminomethyl]-2 -(methylthio)-3-thienyl]sulfonyl]-6-methyl[1,1'-biphenyl]-2-yl]amino]carbon yl]amino]-

Base Information

Chemical Name:Hexanoic acid, 6-[[[[4-amino-3'-[[5-[[[(1,1-dimethylethoxy)carbonyl]amino]iminomethyl]-2 -(methylthio)-3-thienyl]sulfonyl]-6-methyl[1,1'-biphenyl]-2-yl]amino]carbon yl]amino]-
CAS No.:631911-29-0
Molecular Formula:C31H39N5O7S3
Molecular Weight:689.878
Hs Code.:

Hexanoic acid,
6-[[[[4-amino-3'-[[5-[[[(1,1-dimethylethoxy)carbonyl]amino]iminomethyl]-2
-(methylthio)-3-thienyl]sulfonyl]-6-methyl[1,1'-biphenyl]-2-yl]amino]carbon
yl]amino]-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Hexanoic acid, 6-[[[[4-amino-3'-[[5-[[[(1,1-dimethylethoxy)carbonyl]amino]iminomethyl]-2 -(methylthio)-3-thienyl]sulfonyl]-6-methyl[1,1'-biphenyl]-2-yl]amino]carbon yl]amino]-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Hexanoic acid, 6-[[[[4-amino-3'-[[5-[[[(1,1-dimethylethoxy)carbonyl]amino]iminomethyl]-2 -(methylthio)-3-thienyl]sulfonyl]-6-methyl[1,1'-biphenyl]-2-yl]amino]carbon yl]amino]-

There total 9 articles about Hexanoic acid, 6-[[[[4-amino-3'-[[5-[[[(1,1-dimethylethoxy)carbonyl]amino]iminomethyl]-2 -(methylthio)-3-thienyl]sulfonyl]-6-methyl[1,1'-biphenyl]-2-yl]amino]carbon yl]amino]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 6-{3-[3'-[5-(tert-butoxycarbonylamino-imino-methyl)-2-methylsulfanyl-thiophene-3-sulfonyl]-6-methyl-4-(2-trimethylsilanyl-ethoxycarbonylamino)-biphenyl-2-yl]-ureido}-hexanoic acid

: 631911-29-0
6-(3-{4-amino-3'-[5-(tert-butoxycarbonylamino-imino-methyl)-2-methylsulfanyl-thiophene-3-sulfonyl]-6-methyl-biphenyl-2-yl}-ureido)-hexanoic acid

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; hexanes; at 40 ℃; for 4h;

Reference yield:

: 631911-27-8
6-{3-[3'-[5-(tert-butoxycarbonylamino-imino-methyl)-2-methylsulfanyl-thiophene-3-sulfonyl]-6-methyl-4-(2-trimethylsilanyl-ethoxycarbonylamino)-biphenyl-2-yl]-ureido}-hexanoic acid ethyl ester

: 631911-29-0
6-(3-{4-amino-3'-[5-(tert-butoxycarbonylamino-imino-methyl)-2-methylsulfanyl-thiophene-3-sulfonyl]-6-methyl-biphenyl-2-yl}-ureido)-hexanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide / tetrahydrofuran

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 40 °C

With tetrabutyl ammonium fluoride; lithium hydroxide; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2012.06.030

Reference yield:

: C₈H₅BrN₂O₃

: 631911-29-0
6-(3-{4-amino-3'-[5-(tert-butoxycarbonylamino-imino-methyl)-2-methylsulfanyl-thiophene-3-sulfonyl]-6-methyl-biphenyl-2-yl}-ureido)-hexanoic acid

Guidance literature:: Multi-step reaction with 7 steps

2: iron; ammonium chloride / ethanol / 14 h / 85 °C

3: palladium diacetate; triethylamine / 1,4-dioxane / 1 h / 80 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; toluene / 16 h / 80 °C

5: dichloromethane / 0.67 h

6: lithium hydroxide / tetrahydrofuran

7: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 40 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; palladium diacetate; iron; sodium carbonate; ammonium chloride; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; toluene;
DOI:10.1016/j.bmcl.2012.06.030