2-(2-Carboxyanilino)-4-methylbenzoic acid

Base Information

Chemical Name:2-(2-Carboxyanilino)-4-methylbenzoic acid
CAS No.:63329-46-4
Molecular Formula:C15H13NO4
Molecular Weight:271.273
Hs Code.:
DSSTox Substance ID:DTXSID20532494
Wikidata:Q82405136

Synonyms:2-(2-Carboxyanilino)-4-methylbenzoic acid;63329-46-4;SCHEMBL11074883;DTXSID20532494

Suppliers and Price of 2-(2-Carboxyanilino)-4-methylbenzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(2-Carboxyanilino)-4-methylbenzoic acid

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:271.08445790
Heavy Atom Count:20
Complexity:371

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=C(C=C1)C(=O)O)NC2=CC=CC=C2C(=O)O

Technology Process of 2-(2-Carboxyanilino)-4-methylbenzoic acid

There total 2 articles about 2-(2-Carboxyanilino)-4-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4
anthranilic acid

: 7697-27-0
2-bromo-4-methylbenzoic acid

: 63329-46-4
2-<(2-carboxyphenyl)amino>-4-methylbenzoic acid

Guidance literature:: With copper(I) oxide; copper; potassium carbonate; In 2-ethoxy-ethanol; at 120 ℃; for 0.5h;
DOI:10.1021/jm00365a013

Reference yield:

: 584-08-7
potassium carbonate

: 118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4
anthranilic acid

: 7697-27-0
2-bromo-4-methylbenzoic acid

: 63329-46-4
2-<(2-carboxyphenyl)amino>-4-methylbenzoic acid

Guidance literature:: In 2-ethoxy-ethanol; water;

Reference yield:

: 63329-46-4
2-<(2-carboxyphenyl)amino>-4-methylbenzoic acid

: 78847-60-6
9-(4-Methanesulfonylamino-2-methoxy-phenylamino)-6-methyl-acridine-4-carboxylic acid carbamoylmethyl-amide; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 41 percent / conc. H₂SO₄ / 2 h / 90 °C

2: SOCl₂, DMF / 1 h / Heating

3: CH₂Cl₂; H₂O

4: methanol / Heating

With thionyl chloride; sulfuric acid; N,N-dimethyl-formamide; In methanol; dichloromethane; water;
DOI:10.1021/jm00365a013