4H-1,2,4-Triazole, 3-(trans-1-(4-chlorophenyl)-3-fluorocyclobutyl)-4,5-dicyclopropyl-

Base Information

Chemical Name:4H-1,2,4-Triazole, 3-(trans-1-(4-chlorophenyl)-3-fluorocyclobutyl)-4,5-dicyclopropyl-
CAS No.:633317-53-0
Molecular Formula:C18H19ClFN3
Molecular Weight:331.82
Hs Code.:
UNII:BXI2C3DERP
Wikidata:Q27274942
Pharos Ligand ID:R3DX2RST37DP
ChEMBL ID:CHEMBL255259,CHEMBL404095,CHEMBL3127870

Synonyms:3-(1-(4-chlorophenyl)-3-fluorocyclobutyl)-4,5-dicyclopropyl-1,2,4-triazole;MK-0916

Suppliers and Price of 4H-1,2,4-Triazole, 3-(trans-1-(4-chlorophenyl)-3-fluorocyclobutyl)-4,5-dicyclopropyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 4H-1,2,4-Triazole, 3-(trans-1-(4-chlorophenyl)-3-fluorocyclobutyl)-4,5-dicyclopropyl-

Chemical Property:

XLogP3:3.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:331.1251535
Heavy Atom Count:23
Complexity:453

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC1C2=NN=C(N2C3CC3)C4(CC(C4)F)C5=CC=C(C=C5)Cl

Technology Process of 4H-1,2,4-Triazole, 3-(trans-1-(4-chlorophenyl)-3-fluorocyclobutyl)-4,5-dicyclopropyl-

There total 4 articles about 4H-1,2,4-Triazole, 3-(trans-1-(4-chlorophenyl)-3-fluorocyclobutyl)-4,5-dicyclopropyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 862158-94-9
C₁₈H₁₉ClFN₃*H₂O₄S

: 633317-53-0
(3-[1-(4-chlorophenyl)-trans-3-fluorocyclobutyl]4,5-dicyclopropy1-4H-1,2,4-triazole)

Guidance literature:: With sodium hydroxide;

Reference yield: 63.0%

: 1-(4-chlorophenyl)-trans-3-fluorocyclobutane-r-carbohydrazide

: 1453-50-5
N-cyclopropylcyclopropanecarboxamide

: 633317-53-0
(3-[1-(4-chlorophenyl)-trans-3-fluorocyclobutyl]4,5-dicyclopropy1-4H-1,2,4-triazole)

Guidance literature:: With methyl trifluoromethanesulfonate;
DOI:10.1016/j.bmcl.2008.04.014

Reference yield:

: 1-(4-chlorophenyl)-trans-3-fluorocyclobutane-r-carbohydrazide

: 633317-53-0
(3-[1-(4-chlorophenyl)-trans-3-fluorocyclobutyl]4,5-dicyclopropy1-4H-1,2,4-triazole)

Guidance literature:: N-cyclopropylcyclopropanecarboxamide; With trichlorophosphate; In toluene; at 0 - 35 ℃; for 3h;

1-(4-chlorophenyl)-trans-3-fluorocyclobutane-r-carbohydrazide; In toluene; at 0 - 21 ℃;

With sodium hydroxide; acetic acid; triethylamine; more than 3 stages;