Ethanone, 1-(5-broMo-6-fluoro-1H-indazol-1-yl)-

Base Information

• Chemical Name: Ethanone, 1-(5-broMo-6-fluoro-1H-indazol-1-yl)-
• CAS No.: 633335-81-6
• Molecular Formula: C9H6BrFN2O
• Molecular Weight: 257.05900
• Mol file: 633335-81-6.mol

Synonyms:1-(5-bromo-6-fluoro-1H-indazol-1-yl)ethanone;1-acetyl-5-bromo-6-fluoro-1H-indazole;1-ACETYL-5-BROMO-6-FLUOROINDAZOLE;1-(5-Bromo-6-fluoro-indazol-1-yl)ethanone;1H-Indazole,1-acetyl-5-bromo-6-fluoro;

Chemical Property of Ethanone, 1-(5-broMo-6-fluoro-1H-indazol-1-yl)-

Chemical Property:

• PSA: 34.89000
• LogP: 2.59800
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-(5-Bromo-6-fluoro-1H-indazol-1-yl)ethanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethanone, 1-(5-broMo-6-fluoro-1H-indazol-1-yl)-

There total 7 articles about Ethanone, 1-(5-broMo-6-fluoro-1H-indazol-1-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

N-(4-bromo-5-fluoro-2-methylphenyl)acetamide (633335-80-5) → 1-(5-bromo-6-fluoro-1H-indazol-1-yl)ethan-1-one (633335-81-6)

Guidance literature:

With potassium acetate; acetic anhydride; isopentyl nitrite; 18-crown-6 ether; In chloroform; at 65 ℃; for 24h;

Reference yield: 44.0%

4-bromo-5-fluoro-2-methylaniline (52723-82-7) + acetic anhydride (108-24-7) + isopentyl nitrite (110-46-3) → 1-(5-bromo-6-fluoro-1H-indazol-1-yl)ethan-1-one (633335-81-6)

Guidance literature:

4-bromo-5-fluoro-2-methylaniline; acetic anhydride; With potassium acetate; In chloroform; at 10 - 65 ℃; for 2h;

isopentyl nitrite; With 18-crown-6 ether; In chloroform; at 65 ℃; for 12h;

Reference yield:

4-bromo-5-fluoro-2-methylaniline (52723-82-7) + acetic anhydride (108-24-7) → 1-(5-bromo-6-fluoro-1H-indazol-1-yl)ethan-1-one (633335-81-6)

Guidance literature:

4-bromo-5-fluoro-2-methylaniline; acetic anhydride; In chloroform; at 20 ℃; Cooling with ice;

With tert.-butylnitrite; potassium acetate; 18-crown-6 ether; In chloroform; at 75 ℃; for 16h;

With sodium hydrogencarbonate; In dichloromethane; chloroform; water;

upstream raw materials:

N-(4-bromo-5-fluoro-2-methylphenyl)acetamide

acetic anhydride

4-bromo-5-fluoro-2-methylaniline

tert.-butylnitrite

Downstream raw materials:

5-bromo-6-fluoro-1H-indazole

6-fluoro-1H-indazole-5-carbonitrile

6-fluoro-1H-indazole-5-carbaldehyde

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