4-(fluoromethyl)benzoylformate

Base Information

Chemical Name:4-(fluoromethyl)benzoylformate
CAS No.:114996-72-4
Molecular Formula:C9H7 F O3
Molecular Weight:182.15
Hs Code.:
Mol file:114996-72-4.mol

Synonyms:4-(fluoromethyl)benzoylformate

Suppliers and Price of 4-(fluoromethyl)benzoylformate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of 4-(fluoromethyl)benzoylformate

Chemical Property:

Vapor Pressure:0.000191mmHg at 25°C
Boiling Point:315°Cat760mmHg
Flash Point:144.3°C
PSA：54.37000
Density:1.326g/cm³
LogP:1.42340

Purity/Quality:: 99%+ ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-(fluoromethyl)benzoylformate

There total 2 articles about 4-(fluoromethyl)benzoylformate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 168104-57-2
ethyl (4-fluromethyl)benzoylformate

: 114996-72-4
(4-fluromethyl)benzoylformic acid

Guidance literature:: With sodium hydroxide; for 1h;
DOI:10.1021/jm00010a016

Reference yield:

: 76590-57-3
ethyl 2-[4-(bromomethyl)phenyl]-2-oxoacetate

: 114996-72-4
(4-fluromethyl)benzoylformic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / Me₄NHF₂ / acetonitrile / 1.58 h / Heating

2: 75 percent / 2 N aq. NaOH / 1 h

With sodium hydroxide; tetramethylammonium hydrogen difluoride; In acetonitrile;
DOI:10.1021/jm00010a016

Reference yield:

: 114996-72-4
(4-fluromethyl)benzoylformic acid

: (S,R)-FMeQNB

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) α,α-dichloromethyl methyl ether, 2.) Et3N / 1.) 50 deg C, 2 h, 2.) CH2Cl2, RT, overnight

2: tetrahydrofuran / a) dry ice/acetone temp., 2 h, b) RT, overnight

3: 42 percent / aq. KOH / 2 h / 65 °C

4: 17 mg / carbonyldiimidazole / dimethylformamide / Ambient temperature

With potassium hydroxide; Dichloromethyl methyl ether; triethylamine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00010a016