ethyl (4-fluromethyl)benzoylformate

Base Information

Chemical Name:ethyl (4-fluromethyl)benzoylformate
CAS No.:168104-57-2
Molecular Formula:C₁₁H₁₁FO₃
Molecular Weight:210.205
Hs Code.:

Synonyms:ethyl (4-fluromethyl)benzoylformate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl (4-fluromethyl)benzoylformate

Chemical Property:

Purity/Quality:

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MSDS Files:: SDS file from LookChem

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Technology Process of ethyl (4-fluromethyl)benzoylformate

There total 1 articles about ethyl (4-fluromethyl)benzoylformate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 76590-57-3
ethyl 2-[4-(bromomethyl)phenyl]-2-oxoacetate

: 168104-57-2
ethyl (4-fluromethyl)benzoylformate

Guidance literature:: With tetramethylammonium hydrogen difluoride; In acetonitrile; for 1.58333h; Heating;
DOI:10.1021/jm00010a016

Reference yield: 75.0%

: 168104-57-2
ethyl (4-fluromethyl)benzoylformate

: 114996-72-4
(4-fluromethyl)benzoylformic acid

Guidance literature:: With sodium hydroxide; for 1h;
DOI:10.1021/jm00010a016

Reference yield:

: 168104-57-2
ethyl (4-fluromethyl)benzoylformate

: 168104-61-8
(R)-α-hydroxy-α-<4-(fluoromethyl)phenyl>benzeneacetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / 2 N aq. NaOH / 1 h

2: 1.) α,α-dichloromethyl methyl ether, 2.) Et3N / 1.) 50 deg C, 2 h, 2.) CH2Cl2, RT, overnight

3: tetrahydrofuran / a) dry ice/acetone temp., 2 h, b) RT, overnight

4: 42 percent / aq. KOH / 2 h / 65 °C

With potassium hydroxide; sodium hydroxide; Dichloromethyl methyl ether; triethylamine; In tetrahydrofuran;
DOI:10.1021/jm00010a016