2-(4-Methoxybenzyl)piperidine

Base Information

Chemical Name:2-(4-Methoxybenzyl)piperidine
CAS No.:63587-60-0
Molecular Formula:C13H19NO
Molecular Weight:205.29600
Hs Code.:2933399090
European Community (EC) Number:862-941-0
DSSTox Substance ID:DTXSID00398237
Nikkaji Number:J2.861.258C

Synonyms:2-(4-methoxybenzyl)piperidine;63587-60-0;2-(4-methoxy-benzyl)-piperidine;2-[(4-methoxyphenyl)methyl]piperidine;Oprea1_612887;SCHEMBL20109499;DTXSID00398237;BBL020295;MFCD02663573;STK891488;AKOS001475823;AB12064;CS-0234668;FT-0761998;EN300-145385

Suppliers and Price of 2-(4-Methoxybenzyl)piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
2-(4-Methoxybenzyl)piperidine 97%
1g
$ 424.00

American Custom Chemicals Corporation
2-(4-METHOXY-BENZYL)-PIPERIDINE 95.00%
1G
$ 939.89

American Custom Chemicals Corporation
2-(4-METHOXY-BENZYL)-PIPERIDINE 95.00%
100MG
$ 606.38

American Custom Chemicals Corporation
2-(4-METHOXY-BENZYL)-PIPERIDINE 95.00%
5G
$ 1988.91

AK Scientific
2-(4-Methoxybenzyl)piperidine
5g
$ 1046.00

Total 6 raw suppliers

Chemical Property of 2-(4-Methoxybenzyl)piperidine

Chemical Property:

Vapor Pressure:0.000564mmHg at 25°C
Boiling Point:311.4oC at 760 mmHg
PKA:10.28±0.10(Predicted)
Flash Point:128.1oC
PSA：21.26000
Density:1.002g/cm3
LogP:2.70860
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:205.146664230
Heavy Atom Count:15
Complexity:175

Purity/Quality:

98%min ^*data from raw suppliers

2-(4-Methoxybenzyl)piperidine 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)CC2CCCCN2

Technology Process of 2-(4-Methoxybenzyl)piperidine

There total 4 articles about 2-(4-Methoxybenzyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.4%

: 35854-45-6
2-<(4-Methoxyphenyl)methyl>pyridine

: 63587-60-0
(±)-2-(4-methoxybenzyl)piperidine

Guidance literature:: With hydrogen; platinum(IV) oxide; In acetic acid;
DOI:10.1248/cpb.30.180

Reference yield:

: 1121-60-4
pyridine-2-carbaldehyde

: 63587-60-0
(±)-2-(4-methoxybenzyl)piperidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium; iodine / tetrahydrofuran / 60 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: sulfuric acid; palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C

3.1: platinum(IV) oxide; hydrogenchloride; hydrogen / ethanol / 2 h / 20 °C

With hydrogenchloride; platinum(IV) oxide; sulfuric acid; palladium 10% on activated carbon; hydrogen; iodine; magnesium; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/acs.jmedchem.6b01482

Reference yield:

: 104-92-7
1-bromo-4-methoxy-benzene

: 63587-60-0
(±)-2-(4-methoxybenzyl)piperidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium; iodine / tetrahydrofuran / 60 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: sulfuric acid; palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C

3.1: platinum(IV) oxide; hydrogenchloride; hydrogen / ethanol / 2 h / 20 °C

With hydrogenchloride; platinum(IV) oxide; sulfuric acid; palladium 10% on activated carbon; hydrogen; iodine; magnesium; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/acs.jmedchem.6b01482