2-Methoxy-2-(1-naphthyl)propionic Acid

Base Information

• Chemical Name: 2-Methoxy-2-(1-naphthyl)propionic Acid
• CAS No.: 63628-25-1
• Molecular Formula: C14H14O3
• Molecular Weight: 230.25900
• Hs Code.: 2918990090
• European Community (EC) Number: 672-680-2
• UNII: 116NC5P8V4
• DSSTox Substance ID: DTXSID70459107
• Nikkaji Number: J1.582.309G
• Wikidata: Q27251291
• Mol file: 63628-25-1.mol

Synonyms:(S)-2-methoxy-2-(1-naphthyl)propanoic acid;2-methoxy-2-(1-naphthyl)propionic acid;M alphaNP acid

Chemical Property of 2-Methoxy-2-(1-naphthyl)propionic Acid

Chemical Property:

• Vapor Pressure: 3.08E-07mmHg at 25°C
• Melting Point: 161-162°
• Boiling Point: 403.6oC at 760 mmHg
• Flash Point: 154.4oC
• PSA: 46.53000
• Density: 1.204g/cm3
• LogP: 2.78600
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 230.094294304
• Heavy Atom Count: 17
• Complexity: 289

Purity/Quality:

98% ^*data from raw suppliers

2-Methoxy-2-naphthalen-1-yl-propionicAcid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-36-51
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=CC=CC2=CC=CC=C21)(C(=O)O)OC

Technology Process of 2-Methoxy-2-(1-naphthyl)propionic Acid

There total 4 articles about 2-Methoxy-2-(1-naphthyl)propionic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

rac-methyl 2-methoxyl-2-(1-naphthyl)propionate → rac-2-methoxy-2-(naphthalen-1-yl)propanoic acid (63628-25-1)

Guidance literature:

With potassium hydroxide; In methanol; water; at 90 ℃;

DOI:10.1016/j.tetlet.2014.05.037

Reference yield:

1-Bromonaphthalene (90-11-9) → rac-2-methoxy-2-(naphthalen-1-yl)propanoic acid (63628-25-1)

Guidance literature:

Multi-step reaction with 3 steps

1: magnesium / tetrahydrofuran / 0 - 20 °C

2: sodium hydride / tetrahydrofuran / 20 °C

3: potassium hydroxide / methanol; water / 90 °C

With sodium hydride; magnesium; potassium hydroxide; In tetrahydrofuran; methanol; water;

DOI:10.1016/j.tetlet.2014.05.037

Reference yield:

rac-methyl 2-hydroxy-2-(1-naphthyl)propionate (247130-25-2) → rac-2-methoxy-2-(naphthalen-1-yl)propanoic acid (63628-25-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran / 20 °C

2: potassium hydroxide / methanol; water / 90 °C

With sodium hydride; potassium hydroxide; In tetrahydrofuran; methanol; water;

DOI:10.1016/j.tetlet.2014.05.037

upstream raw materials:

1-Bromonaphthalene

rac-methyl 2-hydroxy-2-(1-naphthyl)propionate

Downstream raw materials:

(S)-2-Methoxy-2-naphthalen-1-yl-propionic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

(R)-2-Methoxy-2-naphthalen-1-yl-propionic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

(S)-2-methoxy-2-(naphthalen-1-yl)propionic acid

(R)-α-methoxy-α-methyl-1-naphthaleneacetic acid

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