L-Leucine, N-L-phenylalanyl-, phenylmethyl ester

Base Information

• Chemical Name: L-Leucine, N-L-phenylalanyl-, phenylmethyl ester
• CAS No.: 63649-15-0
• Molecular Formula: C22H28N2O3
• Molecular Weight: 368.476
• Mol file: 63649-15-0.mol

Synonyms:H-Phe-Leu-OBzl;Phe-Leu-OBn;Phe-LeuOBzl*HCl;Phe-Leu-OBzl;phenylalanyl-leucine benzyl ester;

Chemical Property of L-Leucine, N-L-phenylalanyl-, phenylmethyl ester

Chemical Property:

• PSA: 81.42000
• LogP: 3.92190

Purity/Quality:

≥ 98% ^*data from raw suppliers

L-PHENYLALANYL-L-LEUCINE BENZYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Leucine, N-L-phenylalanyl-, phenylmethyl ester

There total 40 articles about L-Leucine, N-L-phenylalanyl-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Boc2-Phe-Leu-OBzl (113568-28-8) → L-phenylalanyl-L-leucine benzyl ester (63649-15-0)

Guidance literature:

With trifluoroacetic acid; at 0 ℃; for 1h;

Reference yield: 93.0%

(S)-4-Methyl-2-[(S)-2-(2-nitro-phenylsulfanylamino)-3-phenyl-propionylamino]-pentanoic acid benzyl ester (71027-08-2) → L-phenylalanyl-L-leucine benzyl ester (63649-15-0)

Guidance literature:

With hydrogenchloride; In methanol;

Reference yield: 90.0%

2-[2-(2-Chloro-3H-inden-1-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid benzyl ester (88099-25-6) → 2-(2-Amino-3-phenyl-propionylamino)-4-methyl-pentanoic acid benzyl ester (63649-15-0,121613-89-6)

Guidance literature:

With piperazino silica reagent 6 loaded with NH; In chloroform; for 1.5h;

DOI:10.1021/jo00288a042

upstream raw materials:

L-Leucine benzyl ester

Nps-L-Phe-OH

L-leucine benzyl ester p-toluenesulfonate

2S-flouren-9-ylmethoxycarbonylamino-3-phenylpropionyl chloride

Downstream raw materials:

(S)-benzyl 2-((S)-2-(2-aminoacetamido)-3-phenylpropanamido)-4-methylpentanoate

Fmoc-Gly-Phe-Leu-OBzl

Boc₂-Gly-Phe-Leu-OBzl

Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucine Benzyl Ester