NPS-PHE-OH DCHA

Base Information

• Chemical Name: NPS-PHE-OH DCHA
• CAS No.: 2688-22-4
• Molecular Formula: C15H14 N2 O4 S
• Molecular Weight: 318.353
• Mol file: 2688-22-4.mol

Synonyms:Alanine,N-[(o-nitrophenyl)thio]-3-phenyl- (6CI,7CI); Alanine,N-[(o-nitrophenyl)thio]-3-phenyl-, L- (8CI); L-N-[(o-Nitrophenyl)thio]phenylalanine;N-(2-Nitrophenylsulfenyl)-L-phenylalanine; N-(o-Nitrophenylsulfenyl)-L-b-phenyl-a-alanine; NSC 287502

Chemical Property of NPS-PHE-OH DCHA

Chemical Property:

• Vapor Pressure: 1.28E-11mmHg at 25°C
• Boiling Point: 519.5°Cat760mmHg
• Flash Point: 268°C
• PSA: 132.48000
• Density: 1.39g/cm³
• LogP: 7.43380
• Storage Temp.: −20°C

Purity/Quality:

99% ^*data from raw suppliers

(S)-2-(((2-Nitrophenyl)thio)amino)-3-phenylpropanoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of NPS-PHE-OH DCHA

There total 6 articles about NPS-PHE-OH DCHA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-nitrobenzenesulfenyl chloride (7669-54-7) → Nps-L-Phe-OH (2688-22-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / H₂O; dioxane / 2 h / Ambient temperature

2: 1 N aq. NaOH / dioxane; tetrahydrofuran / 12 h / Ambient temperature

With sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; water;

DOI:10.1055/s-1985-31254

Reference yield:

NPS-Phe-OMe (17349-27-8) → Nps-L-Phe-OH (2688-22-4)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane;

DOI:10.1021/ja00905a029

Reference yield:

methyl (2S)-2-amino-3-phenylpropanoate (2577-90-4) → Nps-L-Phe-OH (2688-22-4)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / chloroform

2: sodium hydroxide / 1,4-dioxane

With sodium hydroxide; triethylamine; In 1,4-dioxane; chloroform;

DOI:10.1021/ja00905a029

upstream raw materials:

NPS-Phe-OMe

2-(2-nitrophenylthio)-1,2-benzthiazol-3(2H)-one, 1,1,dioxide

L-phenylalanine

2-nitrobenzenesulfenyl chloride

Downstream raw materials:

(S)-4-benzyl-3-(2-nitro-phenylsulfanyl)-oxazolidine-2,5-dione

L-phenylalanyl-L-leucine benzyl ester

NPS-Phe-OMe

NPS-Phe-Tyr-NH₂