Methanone, (4-methoxyphenyl)[2-(4-methoxyphenyl)benzo[b]thien-3-yl]-

Base Information

• Chemical Name: Methanone, (4-methoxyphenyl)[2-(4-methoxyphenyl)benzo[b]thien-3-yl]-
• CAS No.: 63675-96-7
• Molecular Formula: C23H18O3S
• Molecular Weight: 374.46
• Mol file: 63675-96-7.mol

Synonyms:

Chemical Property of Methanone, (4-methoxyphenyl)[2-(4-methoxyphenyl)benzo[b]thien-3-yl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanone, (4-methoxyphenyl)[2-(4-methoxyphenyl)benzo[b]thien-3-yl]-

There total 6 articles about Methanone, (4-methoxyphenyl)[2-(4-methoxyphenyl)benzo[b]thien-3-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(4-methoxyphenyl)benzo[b]thiophene (27884-09-9) + 4-methoxy-benzoyl chloride (100-07-2) → 2-(4-methoxy-phenyl)benzo[b]thiophen-3-yl 4-methoxyphenyl ketone (63675-96-7)

Guidance literature:

With aluminium trichloride; In 1,2-dichloro-ethane; at 0 ℃; for 5h;

DOI:10.1021/jm9903388

Reference yield:

thiophenol (108-98-5) → 2-(4-methoxy-phenyl)benzo[b]thiophen-3-yl 4-methoxyphenyl ketone (63675-96-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide

2: aluminum (III) chloride

With aluminum (III) chloride; potassium hydroxide; 2: |Friedel-Crafts Acylation;

DOI:10.1111/cbdd.12239

Reference yield:

benzothiophene-2,3-dicarboxylic acid (37412-26-3) → 2-(4-methoxy-phenyl)benzo[b]thiophen-3-yl 4-methoxyphenyl ketone (63675-96-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetic anhydride / Reflux

2.1: aluminum (III) chloride / 1,2-dichloro-ethane / 1 h / Inert atmosphere; Schlenk technique

2.2: 9 h / 20 °C / Inert atmosphere; Schlenk technique

3.1: silver carbonate; triphenyl-arsane; palladium dichloride / dimethyl sulfoxide / 150 °C / Inert atmosphere; Schlenk technique

With aluminum (III) chloride; triphenyl-arsane; acetic anhydride; silver carbonate; palladium dichloride; In dimethyl sulfoxide; 1,2-dichloro-ethane;

DOI:10.1039/c8ob00010g

upstream raw materials:

2-(4-methoxyphenyl)benzo[b]thiophene

4-methoxy-benzoyl chloride

2-Bromo-4'-methoxyacetophenone

thiophenol

Downstream raw materials:

methyl 4-[1-[2-(4-methoxyphenyl)benzo[b]thiophen-3-yl]ethenyl]phenyl ether

2-(4-hydroxy-phenyl)benzo[b]thiophen-3-yl 4-[2-(1-pyrrolidinyl)ethoxy]-phenyl ketone

2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl 4-hydroxyphenyl ketone

4-[1-[2-(4-methoxyphenyl)benzo[b]thiophen-3-yl]ethenyl]phenol