methyl 4-methylpiperazine-1-carboxylate

Base Information

• Chemical Name: methyl 4-methylpiperazine-1-carboxylate
• CAS No.: 7560-85-2
• Molecular Formula: C7H14N2O2
• Molecular Weight: 158.2
• Hs Code.: 2933599090
• Mol file: 7560-85-2.mol

Synonyms:4-methyl-piperazine-1-carboxylic acid methyl ester;4-Methyl-piperazin-1-carbonsaeure-methylester;methyl 4-methyl-1-piperazine carboxylate;

Chemical Property of methyl 4-methylpiperazine-1-carboxylate

Chemical Property:

• Vapor Pressure: 0.194mmHg at 25°C
• Boiling Point: 210.2°Cat760mmHg
• Flash Point: 81°C
• PSA: 32.78000
• Density: 1.082g/cm³
• LogP: -0.12400
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

methyl4-methylpiperazine-1-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 4-methylpiperazine-1-carboxylate

There total 2 articles about methyl 4-methylpiperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

1-methyl-piperazine (109-01-3) + methyl chloroformate (79-22-1) → methyl 4-methylpiperazine-1-carboxylate (7560-85-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 3.08333h;

DOI:10.1016/j.bmc.2008.10.045

Reference yield:

methyl piperazine-1-carboxylate (50606-31-0) → methyl 4-methylpiperazine-1-carboxylate (7560-85-2)

Guidance literature:

With methyl p-toluene sulfonate;

DOI:10.1021/jo01159a018

Reference yield: 82.0%

methyl 4-methylpiperazine-1-carboxylate (7560-85-2) → N,N'-dimethylpiperazine (106-58-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 0.5h; Heating;

DOI:10.1016/S0040-4039(00)98209-1

upstream raw materials:

methyl piperazine-1-carboxylate

1-methyl-piperazine

methyl chloroformate

Downstream raw materials:

1-dodecyl-4-methoxycarbonyl-1-methyl-piperazinium; bromide

N,N'-dimethylpiperazine

Refernces

• 1、 Ram, Siya,Ehrenkaufer, Richard E.. "RAPID REDUCTIVE-CARBOXYLATION OF SECONDARY AMINES. ONE POT SYNTHESIS OF TERTIARY N-METHYLATED AMINES". . p. 5367 - 5370. Retrieved 2007/10/02.