METHYL PIPERAZINE-1-CARBOXYLATE

Base Information

• Chemical Name: METHYL PIPERAZINE-1-CARBOXYLATE
• CAS No.: 50606-31-0
• Molecular Formula: C6 H12 N2 O2
• Molecular Weight: 144.173
• Hs Code.: 2933599090
• Mol file: 50606-31-0.mol

Synonyms:1-(Methoxycarbonyl)piperazine;Methyl 1-piperazinecarboxylate;N-Methoxycarbonylpiperazine;

Chemical Property of METHYL PIPERAZINE-1-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 0.125mmHg at 25°C
• Melting Point: 173-175 °C
• Refractive Index: 1.465
• Boiling Point: 218.5 ºC at 760 mmHg
• PKA: 8.45±0.10(Predicted)
• Flash Point: 85.9 ºC
• PSA: 41.57000
• Density: 1.099 g/cm³
• LogP: -0.07530
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(Methoxycarbonyl)piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-(Methoxycarbonyl)piperazine is used in the synthesis of piperazine derivatives as kinase inhibitors for the treatment of diabetes, diabetic complications and other dieases.

Technology Process of METHYL PIPERAZINE-1-CARBOXYLATE

There total 9 articles about METHYL PIPERAZINE-1-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine (383865-57-4) → methyl piperazine-1-carboxylate (50606-31-0) + 4-(4-Methoxy-7-morpholin-4-yl-benzothiazol-2-yl-carbamoyl)-piperazine-1-carboxylic acid methyl ester

Guidance literature:

Reference yield: 54.0%

→ methyl piperazine-1-carboxylate (50606-31-0)

Guidance literature:

Reference yield: 36.0%

piperazine (110-85-0) + methyl chloroformate (79-22-1) → methyl piperazine-1-carboxylate (50606-31-0)

Guidance literature:

With C₂₁H₃₀N₄O₅; In dichloromethane; at 20 ℃; for 0.5h;

upstream raw materials:

piperazine

p-nitrophenyl methyl carbonate

1-(tert-butyl) 4-methyl piperazine-1,4-dicarboxylate

4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine

Downstream raw materials:

C₁₃H₁₇N₃O₄

methyl 4-(3-amino-2-fluorobenzyl)piperazine-1-carboxylate

C₁₃H₁₉N₃O₂

methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate

Refernces

• 1、 -. "ALTERNATE PROCESSES FOR THE PREPARATION OF OMECAMTIV MECARBIL". Page/Page column 20-21. . Retrieved 2021/04/17.
• 2、 Zulli, Allison L.,Aimone, Lisa D.,Mathiasen, Joanne R.,Gruner, John A.,Raddatz, Rita,Bacon, Edward R.,Hudkins, Robert L.. "Substituted phenoxypropyl-(R)-2-methylpyrrolidine aminomethyl ketones as histamine-3 receptor inverse agonists". scheme or table. p. 2807 - 2810. Retrieved 2012/05/20.