Ethyl 3-amino-4-(tert-butylamino)benzoate

Base Information

• Chemical Name: Ethyl 3-amino-4-(tert-butylamino)benzoate
• CAS No.: 637041-67-9
• Molecular Formula: C13H20N2O2
• Molecular Weight: 236.31000
• Hs Code.: 2922499990
• Mol file: 637041-67-9.mol

Synonyms:

Chemical Property of Ethyl 3-amino-4-(tert-butylamino)benzoate

Chemical Property:

• PSA: 64.35000
• LogP: 3.31010

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl 3-amino-4-(tert-butylamino)benzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 3-amino-4-(tert-butylamino)benzoate

There total 4 articles about Ethyl 3-amino-4-(tert-butylamino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4-(tert-butylamino)-3-nitrobenzoate (637041-66-8) → ethyl 3-amino-4-(tert-butylamino)benzoate (637041-67-9)

Guidance literature:

With hydrogen; palladium dihydroxide; In methanol; for 24h; under 760 Torr;

DOI:10.1055/s-2003-40888

Reference yield:

ethyl 4-chloro-3-nitrobenzoate (16588-16-2) → ethyl 3-amino-4-(tert-butylamino)benzoate (637041-67-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / dimethylsulfoxide / 6 h / 70 °C

2: H₂ / 20 percent Pd(OH)2/C / methanol / 24 h / 760 Torr

With hydrogen; palladium dihydroxide; In methanol; dimethyl sulfoxide;

DOI:10.1055/s-2003-40888

Reference yield:

3-nitro-4-fluorobenzoic acid (453-71-4) → ethyl 3-amino-4-(tert-butylamino)benzoate (637041-67-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / 8 h / Reflux

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3: ammonium formate; palladium 10% on activated carbon / 0.03 h / 100 °C / Microwave irradiation

With sulfuric acid; palladium 10% on activated carbon; ammonium formate; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.3109/14756366.2012.729828

upstream raw materials:

ethyl 4-(tert-butylamino)-3-nitrobenzoate

ethyl 4-chloro-3-nitrobenzoate

3-nitro-4-fluorobenzoic acid

ethyl 4-fluoro-3-nitrobenzoate

Refernces

• 1、 Beaulieu, Pierre L.,Hache, Bruno,Von Moos, Elisabeth. "A practical oxone - Mediated, high-throughput, solution-phase synthesis of benzimidazoles from 1,2-phenylenediamines and aldehydes and its application to preparative scale synthesis". . p. 1683 - 1692. Retrieved 2007/10/03.