Cytosine-5-carboxylic acid

Base Information

Chemical Name:Cytosine-5-carboxylic acid
CAS No.:3650-93-9
Molecular Formula:C5H5 N3 O3
Molecular Weight:155.113
Hs Code.:2933599090
European Community (EC) Number:222-890-1
NSC Number:9309
UNII:760CU98B9K
DSSTox Substance ID:DTXSID70190003
Nikkaji Number:J205.569D
Wikidata:Q27146335
Mol file:3650-93-9.mol

Synonyms:5-carboxycytosine;5caC nucleoside

Suppliers and Price of Cytosine-5-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-Carboxycytosine
500mg
$ 580.00

Matrix Scientific
4-Amino-2-hydroxypyrimidine-5-carboxylic acid
500mg
$ 315.00

Crysdot
4-Amino-2-hydroxy-5-pyrimidinecarboxylicacid 95+%
1g
$ 392.00

Chemenu
4-amino-2-hydroxypyrimidine-5-carboxylicacid 95%
1g
$ 371.00

Biosynth Carbosynth
5-Carboxycytosine
25 mg
$ 125.00

Biosynth Carbosynth
5-Carboxycytosine
100 mg
$ 270.00

Biosynth Carbosynth
5-Carboxycytosine
50 mg
$ 200.00

Biosynth Carbosynth
5-Carboxycytosine
250 mg
$ 550.00

Biosynth Carbosynth
5-Carboxycytosine
10 mg
$ 70.00

American Custom Chemicals Corporation
4-AMINO-5-CARBOXY-2-HYDROXYPYRIMIDINE 95.00%
1G
$ 808.50

Total 16 raw suppliers

Chemical Property of Cytosine-5-carboxylic acid

Chemical Property:

Melting Point:256-257 °C
Boiling Point:°Cat760mmHg
PKA:-3.50±0.20(Predicted)
Flash Point:°C
PSA：109.33000
Density:1.88g/cm³
LogP:0.04380
Storage Temp.:Refrigerator, under inert atmosphere
Solubility.:Aqueous Base (Slightly)
XLogP3:-0.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:155.03309103
Heavy Atom Count:11
Complexity:279

Purity/Quality:

97% ^*data from raw suppliers

5-Carboxycytosine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=NC(=O)NC(=C1C(=O)O)N
Uses Cytosine derivatives, such as 5-Carboxylcytosine, are involved with a wide variety of biological functions including cytosine methylation, gene expression, genome stability, and chromatin modification. In addition, 5-Carboxylcytosine interacts with the RNA polymerase II elongation complex that can influence the pluripotent states during early embryonic development.

Technology Process of Cytosine-5-carboxylic acid

There total 17 articles about Cytosine-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.8%

: 20187-46-6
ethyl cytosine-5-carboxylate

: 3650-93-9
5-carboxylcytosine

Guidance literature:: With sodium hydroxide; at 70 ℃; for 0.5h; Reagent/catalyst; Temperature;

Reference yield: 62.0%

: 5-carboxyl-2′-deoxy-(N¹,N³-N)cytidine

: 3650-93-9
5-carboxylcytosine

Guidance literature:: 5-carboxyl-2′-deoxy-(N¹,N³-N)cytidine; With hydrogenchloride; water; at 20 ℃; for 48h; Inert atmosphere;

at 45 ℃; for 15h; Inert atmosphere;
DOI:10.1002/anie.202107277

Reference yield:

: 1361013-63-9
5-carboxylmethyl-3',5'-(tert-butyldimethylsilyl)-2'-deoxycytidine

: 3650-93-9
5-carboxylcytosine

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine hydrogenfluoride / ethyl acetate / 14 h / 21 °C / Inert atmosphere

1.2: 18 h / 20 °C / Inert atmosphere

2.1: water; hydrogenchloride / 48 h / 20 °C / Inert atmosphere

2.2: 15 h / 45 °C / Inert atmosphere

With hydrogenchloride; water; pyridine hydrogenfluoride; In ethyl acetate;
DOI:10.1002/anie.202107277