2-[2-(4-aminophenyl)ethyl]-5-[2-tert-butyl-4-(hydroxymethyl)-5-methyl-phenyl]sulfanyl-6-hydroxy-2-phenyl-3H-pyran-4-one

Base Information

• Chemical Name: 2-[2-(4-aminophenyl)ethyl]-5-[2-tert-butyl-4-(hydroxymethyl)-5-methyl-phenyl]sulfanyl-6-hydroxy-2-phenyl-3H-pyran-4-one
• CAS No.: 197915-37-0
• Molecular Formula: C31H35NO4S
• Molecular Weight: 517.6789
• Mol file: 197915-37-0.mol

Synonyms:

Chemical Property of 2-[2-(4-aminophenyl)ethyl]-5-[2-tert-butyl-4-(hydroxymethyl)-5-methyl-phenyl]sulfanyl-6-hydroxy-2-phenyl-3H-pyran-4-one

Chemical Property:

• Vapor Pressure: 2.44E-18mmHg at 25°C
• Boiling Point: 660.4°Cat760mmHg
• Flash Point: 353.2°C
• Density: 1.26g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[2-(4-aminophenyl)ethyl]-5-[2-tert-butyl-4-(hydroxymethyl)-5-methyl-phenyl]sulfanyl-6-hydroxy-2-phenyl-3H-pyran-4-one

There total 15 articles about 2-[2-(4-aminophenyl)ethyl]-5-[2-tert-butyl-4-(hydroxymethyl)-5-methyl-phenyl]sulfanyl-6-hydroxy-2-phenyl-3H-pyran-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

N-(4-{2-[5-(2-tert-butyl-4-hydroxymethyl-5-methyl-phenylsulfanyl)-4-hydroxy-6-oxo-2-phenyl-3,6-dihydro-2H-pyran-2-yl]-ethyl}-phenyl)-acetamide → 6-[2-(4-aminophenyl)ethyl]-3-(2-tert-butyl-4-hydroxymethyl-5-methyl-phenylsulfanyl)-4-hydroxy-6-phenyl-5,6-dihydro-pyran-2-one (197915-37-0)

Guidance literature:

With sodium hydroxide; In methanol; water; Heating;

DOI:10.1016/S0968-0896(99)00215-1

Reference yield:

potassium carbonate (584-08-7) + toluene-4-thiosulfonic acid S-(2-tert-butyl-4-hydroxymethyl-5-methyl-phenyl) ester (207737-06-2) + 6-[2-(4-acetylaminophenyl)ethyl]-4-hydroxy-6-phenyl-5,6-dihydropyran-2-one (207736-93-4) → 6-[2-(4-aminophenyl)ethyl]-3-(2-tert-butyl-4-hydroxymethyl-5-methyl-phenylsulfanyl)-4-hydroxy-6-phenyl-5,6-dihydro-pyran-2-one (197915-37-0)

Guidance literature:

With sodium hydroxide; In methanol; water; N,N-dimethyl-formamide;

Reference yield:

2-tert-Butyl-5-methylphenol (88-60-8) → 6-[2-(4-aminophenyl)ethyl]-3-(2-tert-butyl-4-hydroxymethyl-5-methyl-phenylsulfanyl)-4-hydroxy-6-phenyl-5,6-dihydro-pyran-2-one (197915-37-0)

Guidance literature:

Multi-step reaction with 9 steps

1: Br₂ / CCl₄

2: NaH / tetrahydrofuran

3: 1.) n-BuLi

4: H₂SO₄

5: 1.) NaH / 1.) DMF, 2.) DMF

6: 240 °C

7: DIBAL / CH₂Cl₂

8: pyridine / CCl₄

9: K₂CO₃ / dimethylformamide

With pyridine; n-butyllithium; sulfuric acid; bromine; sodium hydride; diisobutylaluminium hydride; potassium carbonate; In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm970522y

upstream raw materials:

toluene-4-thiosulfonic acid S-(2-tert-butyl-4-hydroxymethyl-5-methyl-phenyl) ester

N-(4-(3-oxo-3-phenylpropyl)phenyl)acetamide

6-[2-(4-acetylaminophenyl)ethyl]-4-hydroxy-6-phenyl-5,6-dihydropyran-2-one

2-tert-Butyl-5-methylphenol