3-(P-TOLYLOXY)PIPERIDINE

Base Information

• Chemical Name: 3-(P-TOLYLOXY)PIPERIDINE
• CAS No.: 63843-39-0
• Molecular Formula: C12H17NO
• Molecular Weight: 191.26900
• Hs Code.: 2933399090
• Mol file: 63843-39-0.mol

Synonyms:(R,S)-3-(p-tolyloxy)piperidine;3-(4-Methylphenoxy)-piperidine HCl;3-(P-TolYl-Oxy)Piperidine;

Chemical Property of 3-(P-TOLYLOXY)PIPERIDINE

Chemical Property:

• Vapor Pressure: 0.00117mmHg at 25°C
• Boiling Point: 299.8oC at 760 mmHg
• Flash Point: 120.9oC
• PSA: 21.26000
• Density: 1.016g/cm3
• LogP: 2.45460

Purity/Quality:

99% ^*data from raw suppliers

3-(4-Methylphenoxy)piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(P-TOLYLOXY)PIPERIDINE

There total 2 articles about 3-(P-TOLYLOXY)PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-hydroxypiperazine (6859-99-0) + 4-tolyl iodide (624-31-7) → N-p-tolylpiperidin-3-ol + (R,S)-3-(p-tolyloxy)piperidine (63843-39-0)

Guidance literature:

With caesium carbonate; copper(l) iodide; In tetrahydrofuran; at 100 ℃; for 20h; Title compound not separated from byproducts.;

DOI:10.1021/ja068926f

Reference yield:

→ (R,S)-3-(p-tolyloxy)piperidine (63843-39-0)

Guidance literature:

entspr. 1-Benzylpiperidin, H2/Pd/C;

DOI:10.1021/jm00201a018

Reference yield: 87.0%

(R,S)-3-(p-tolyloxy)piperidine (63843-39-0) + o-chlorobenzoyl chloride (609-65-4) → (R,S)-N,N-(2-(m-tolyloxy))pentamethylene-2-chlorobenzamide (1463965-08-3)

Guidance literature:

With pyridine; for 3h; Reflux;

DOI:10.1002/cmdc.201200407

upstream raw materials:

3-hydroxypiperazine

4-tolyl iodide

Downstream raw materials:

(R,S)-N,N-(2-(m-tolyloxy))pentamethylene-2-chlorobenzamide

Refernces

• 1、 Helsley,Strupczewski,Woodward. "Piperidylalkylindoles. 1. Hypotensive activity of 3-[2-(phenoxypiperidyl)ethyl]indoles". . p. 309 - 312. Retrieved 2007/10/05.