Technology Process of tert-Butyl (2S)-2-(2-oxoethyl)piperidine-1-carboxylate
There total 15 articles about tert-Butyl (2S)-2-(2-oxoethyl)piperidine-1-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(S)-2-(2-hydroxy-ethyl)-piperidine-1-carboxylic acid tert-butyl ester;
With
phosgene; dimethyl sulfoxide;
In
dichloromethane;
at -78 ℃;
for 0.333333h;
Inert atmosphere;
With
triethylamine;
In
dichloromethane; dimethyl sulfoxide;
at 20 ℃;
for 4h;
Inert atmosphere;
DOI:10.1039/c2ob25880c
- Guidance literature:
-
With
(R)-(-)-α,α-bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanoltrimethylsilyl ether;
In
methanol; 1,2-dichloro-ethane;
at -25 ℃;
for 240h;
optical yield given as %ee;
enantioselective reaction;
DOI:10.1021/ol300342n
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triphenylphosphine / tetrahydrofuran; water / 15 h
1.2: 12 h
2.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 5 h / 20 °C
3.1: (R)-(-)-α,α-bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanoltrimethylsilyl ether / methanol; 1,2-dichloro-ethane / 240 h / -25 °C
With
Hoveyda-Grubbs catalyst second generation; (R)-(-)-α,α-bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanoltrimethylsilyl ether; triphenylphosphine;
In
tetrahydrofuran; methanol; dichloromethane; water; 1,2-dichloro-ethane;
3.1: intramolecular Michael addition;
DOI:10.1021/ol300342n
