6-Oxabicyclo[3.2.1]oct-2-en-7-one, 1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[(4-nitrophenyl)methoxy]-, (1R,4R,5R)-

Base Information

• Chemical Name: 6-Oxabicyclo[3.2.1]oct-2-en-7-one, 1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[(4-nitrophenyl)methoxy]-, (1R,4R,5R)-
• CAS No.: 639806-90-9
• Molecular Formula: C20H27NO6Si
• Molecular Weight: 405.523
• Mol file: 639806-90-9.mol

Synonyms:(1R,3R,4R)-1-(tert-butyldimethylsilyloxy)-4-(4'-nitrobenzyloxy)cyclohex-5-ene-1,3-carbolactone;(1R,4R,5R)-1-(tert-Butyl-dimethyl-silanyloxy)-4-(4-nitro-benzyloxy)-6-oxa-bicyclo[3.2.1]oct-2-en-7-one;

Chemical Property of 6-Oxabicyclo[3.2.1]oct-2-en-7-one, 1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[(4-nitrophenyl)methoxy]-, (1R,4R,5R)-

Chemical Property:

• PSA: 90.58000
• LogP: 4.64910

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Oxabicyclo[3.2.1]oct-2-en-7-one, 1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[(4-nitrophenyl)methoxy]-, (1R,4R,5R)-

There total 2 articles about 6-Oxabicyclo[3.2.1]oct-2-en-7-one, 1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[(4-nitrophenyl)methoxy]-, (1R,4R,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

1-bromomethyl-4-nitro-benzene (100-11-8) → (1R,3R,4R)-1-(tert-butyldimethylsilyloxy)-4-(4'-nitrobenzyloxy)cyclohex-5-en-1,3-carbolactone (639806-90-9)

Guidance literature:

(1R,3R,4R)-1-(tert-butyldimethylsilyloxy)-4-hydroxycyclohex-5-ene-1,3-carbolactone; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃;

1-bromomethyl-4-nitro-benzene; With 15-crown-5; tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 48h;

Reference yield: 24.0%

1-bromomethyl-4-nitro-benzene (100-11-8) + (1R,3R,4R)-1-(tert-butyldimethylsilyloxy)-4-hydroxycyclohex-5-ene-1,3-carbolactone (356760-74-2) → (1R,3R,4R)-1-(tert-butyldimethylsilyloxy)-4-(4'-nitrobenzyloxy)cyclohex-5-en-1,3-carbolactone (639806-90-9)

Guidance literature:

(1R,3R,4R)-1-(tert-butyldimethylsilyloxy)-4-hydroxycyclohex-5-ene-1,3-carbolactone; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

1-bromomethyl-4-nitro-benzene; With 15-crown-5; tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 48h;

DOI:10.1021/jm030987q

Reference yield: 43.0%

(1R,3R,4R)-1-(tert-butyldimethylsilyloxy)-4-(4'-nitrobenzyloxy)cyclohex-5-en-1,3-carbolactone (639806-90-9) → (1R,3R,4R)-1-hydroxy-4-(4'-nitrobenzyloxy)cyclohex-5-en-1,3-carbolactone (639806-92-1)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 0.5h;

DOI:10.1021/jm030987q

upstream raw materials:

1-bromomethyl-4-nitro-benzene

(1R,3R,4R)-1-(tert-butyldimethylsilyloxy)-4-hydroxycyclohex-5-ene-1,3-carbolactone

Downstream raw materials:

(1R,3R,4R)-1-hydroxy-4-(4'-nitrobenzyloxy)cyclohex-5-en-1,3-carbolactone