4,7-Dimethoxyphthalide

Base Information

Chemical Name:4,7-Dimethoxyphthalide
CAS No.:64019-78-9
Molecular Formula:C10H10O4
Molecular Weight:194.18400
Hs Code.:
DSSTox Substance ID:DTXSID60395267
Wikidata:Q82195240

Synonyms:4,7-dimethoxyphthalide;64019-78-9;SCHEMBL6204130;DTXSID60395267;ABFJCCZUMNBAAI-UHFFFAOYSA-N

Suppliers and Price of 4,7-Dimethoxyphthalide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4,7-Dimethoxyphthalide

Chemical Property:

PSA：44.76000
LogP:1.37420
XLogP3:1.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:194.05790880
Heavy Atom Count:14
Complexity:228

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C2COC(=O)C2=C(C=C1)OC

Technology Process of 4,7-Dimethoxyphthalide

There total 1 articles about 4,7-Dimethoxyphthalide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 94930-66-2
methyl 2-formyl-3,6-dimethoxybenzoate

: 64019-78-9
4,7-dimethoxy-phthalide

: 126838-56-0
methyl 3,6-dimethoxy-2-methylbenzoate

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 6h; under 2585.81 Torr;
DOI:10.1016/j.tetlet.2008.04.112

Reference yield: 86.0%

: 64019-78-9
4,7-dimethoxy-phthalide

: 177036-31-6
4,7-dihydroxyisobenzofuran-1(3H)-one

Guidance literature:: 4,7-dimethoxy-phthalide; With pyridine hydrochloride; at 200 ℃; for 2.5h;

With hydrogenchloride; In water; at 90 ℃; for 1h;
DOI:10.1021/acs.orglett.7b00902

Reference yield:

: 64019-78-9
4,7-dimethoxy-phthalide

: 89449-74-1
dibenzoyl-2,3 dimethoxy-1,4 benzene

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / N-bromosuccinimide / dibenzoyl peroxide / CCl₄ / 0.75 h / Heating

2: 1.) magnesium / 1.) ether, 2.) benzene, reflux, 3 h

3: 70 percent / cerium(IV) ammonium nitrate / H₂O; acetonitrile / 0.5 h / Ambient temperature

With N-Bromosuccinimide; ammonium cerium(IV) nitrate; magnesium; dibenzoyl peroxide; In tetrachloromethane; water; acetonitrile;
DOI:10.1055/s-1983-30608