2-Methyl-3-(4-methylphenyl)-4(3H)-quinazolinone

Base Information

• Chemical Name: 2-Methyl-3-(4-methylphenyl)-4(3H)-quinazolinone
• CAS No.: 22316-59-2
• Molecular Formula: C16H14 N2 O
• Molecular Weight: 250.3
• DSSTox Substance ID: DTXSID50176860
• Nikkaji Number: J479.424I
• Wikidata: Q83047187
• Mol file: 22316-59-2.mol

Synonyms:22316-59-2;2-Methyl-3-(4-methylphenyl)-4(3H)-quinazolinone;2-methyl-3-(4-methylphenyl)-3,4-dihydroquinazolin-4-one;2-methyl-3-(4-methylphenyl)quinazolin-4-one;4(3H)-Quinazolinone, 2-methyl-3-(4-methylphenyl)-;2-Methyl-3-(p-tolyl)-4(3H)-quinazolinone;IFLab1_001135;SCHEMBL2631381;DTXSID50176860;HMS1415D13;STL304753;AKOS000600182;CCG-236036;IDI1_009002;2-methyl-3-p-tolyl-4(3h)-quinazolinone;2-Methyl-3-p-tolylquinazoline-4(3H)-one;LS-141060;CS-0219452;EN300-04063;Quinazolin-4(3H)-one, 2-methyl-3-(p-tolyl)-;2-methyl-3-(4-methylphenyl)quinazolin-4(3H)-one;AE-641/05013010;SR-01000396838;SR-01000396838-1;2-Methyl-3-(4-methylphenyl)-4(3H)-quinazolinone #;Quinazolin-4(3H)-one, 2-methyl-3-(4-methylphenyl)-;Z56886509

Chemical Property of 2-Methyl-3-(4-methylphenyl)-4(3H)-quinazolinone

Chemical Property:

• Vapor Pressure: 1.99E-07mmHg at 25°C
• Boiling Point: 424.9°Cat760mmHg
• Flash Point: 210.8°C
• Density: 1.16g/cm³
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 250.110613074
• Heavy Atom Count: 19
• Complexity: 382

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)N2C(=NC3=CC=CC=C3C2=O)C

Technology Process of 2-Methyl-3-(4-methylphenyl)-4(3H)-quinazolinone

There total 25 articles about 2-Methyl-3-(4-methylphenyl)-4(3H)-quinazolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

Me2CuLi*LiCN + 2-p-Tolyliminomethyleneamino-benzoic acid ethyl ester (1026085-87-9) → 2-methyl-3-p-tolyl-4(3H)-quinazolinone (22316-59-2)

Guidance literature:

In tetrahydrofuran; at -78 ℃; for 1.2h;

DOI:10.1055/s-0032-1316773

Reference yield: 94.0%

dilithium dimethylcyanocuprate + 2-p-Tolyliminomethyleneamino-benzoic acid ethyl ester (1026085-87-9) → 2-methyl-3-p-tolyl-4(3H)-quinazolinone (22316-59-2)

Guidance literature:

at -78 ℃; for 1.2h;

DOI:10.1055/s-0032-1316773

Reference yield: 94.0%

p-toluidine (106-49-0,12221-03-3) + anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) + Triethyl orthoacetate (78-39-7) → 2-methyl-3-p-tolyl-4(3H)-quinazolinone (22316-59-2)

Guidance literature:

With Nafion-H; for 0.0333333h; microwave irradiation;

DOI:10.1055/s-2006-950428

upstream raw materials:

p-toluidine

o-acetylamino-benzoic acid

N,N'-di(p-tolyl)acetamidine

anthranilic acid

Downstream raw materials:

2-(2-Oxo-2-pyridin-2-yl-ethyl)-3-p-tolyl-3H-quinazolin-4-one

2-(2-Oxo-2-pyridin-3-yl-ethyl)-3-p-tolyl-3H-quinazolin-4-one

2-[2-Oxo-2-(4 pyridyl)ethyl]-3-p-tolyl-4(3H)-quinazolinone

2-(3-oxo-3-p-tolyl-propenyl)-3-p-tolyl-3H-quinazolin-4-one