3-[[(tert-Butyl)lsilyl]oxy]-5-hydroxy-benzeneMethanol

Base Information

• Chemical Name: 3-[[(tert-Butyl)lsilyl]oxy]-5-hydroxy-benzeneMethanol
• CAS No.: 641571-45-1
• Molecular Formula: C13H22O3Si
• Molecular Weight: 254.39700
• Mol file: 641571-45-1.mol

Synonyms:3-[[(tert-Butyl)lsilyl]oxy]-5-hydroxy-benzenemethanol;

Chemical Property of 3-[[(tert-Butyl)lsilyl]oxy]-5-hydroxy-benzeneMethanol

Chemical Property:

• PSA: 49.69000
• LogP: 3.26850
• Storage Temp.: Refrigerator
• Solubility.: Ethyl Acetate

Purity/Quality:

3-[[(tert-Butyl)lsilyl]oxy]-5-hydroxy-benzenemethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Protected 3,5-Dihydroxybenzyl Alcohol (D451900). A dendrimer building block.

Technology Process of 3-[[(tert-Butyl)lsilyl]oxy]-5-hydroxy-benzeneMethanol

There total 3 articles about 3-[[(tert-Butyl)lsilyl]oxy]-5-hydroxy-benzeneMethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.4%

methyl 3-{[(tert-butyl)dimethylsilyl]oxy}-5-hydroxybenzoate (174309-11-6) → 3-{[(tert-butyl)dimethylsilyl]oxy}-5-hydroxybenzyl alcohol (641571-45-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1039/b511555h

Reference yield:

1-carbomethoxy-3,5-dihydroxybenzene (2150-44-9) → 3-{[(tert-butyl)dimethylsilyl]oxy}-5-hydroxybenzyl alcohol (641571-45-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 47.8 percent / imidazole / tetrahydrofuran / 24 h / 20 °C

2: 97.4 percent / LiAlH₄ / tetrahydrofuran / 2 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1039/b511555h

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 3-{[(tert-butyl)dimethylsilyl]oxy}-5-hydroxybenzyl alcohol (641571-45-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 47.8 percent / imidazole / tetrahydrofuran / 24 h / 20 °C

2: 97.4 percent / LiAlH₄ / tetrahydrofuran / 2 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1039/b511555h

upstream raw materials:

methyl 3-{[(tert-butyl)dimethylsilyl]oxy}-5-hydroxybenzoate

1-carbomethoxy-3,5-dihydroxybenzene

tert-butyldimethylsilyl chloride

Downstream raw materials:

3-{[(tert-butyl)dimethylsilyl]oxy}-5-[(2,3,4,5,6-pentafluorobenzyl)oxy]benzyl alcohol

Refernces