benzyl 2,5-bis(benzyloxy)benzoate

Base Information

• Chemical Name: benzyl 2,5-bis(benzyloxy)benzoate
• CAS No.: 78283-37-1
• Molecular Formula: C28H24O4
• Molecular Weight: 424.496
• Mol file: 78283-37-1.mol

Synonyms:

Chemical Property of benzyl 2,5-bis(benzyloxy)benzoate

Chemical Property:

• Vapor Pressure: 3.89E-14mmHg at 25°C
• Boiling Point: 595.2°Cat760mmHg
• Flash Point: 255.8°C
• Density: 1.187g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of benzyl 2,5-bis(benzyloxy)benzoate

There total 2 articles about benzyl 2,5-bis(benzyloxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2,5-dihydroxybenzoic acid. (490-79-9) + benzyl chloride (100-44-7) → benzyl 2,5-bis(benzyloxy)benzoate (78283-37-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 20h;

DOI:10.1248/cpb.29.744

Reference yield: 87.0%

2,5-dihydroxybenzoic acid. (490-79-9) + benzyl bromide (100-39-0) → benzyl 2,5-bis(benzyloxy)benzoate (78283-37-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.bmcl.2011.10.119

Reference yield: 91.0%

benzyl 2,5-bis(benzyloxy)benzoate (78283-37-1) → 2,5-bis(benzyloxy)benzoic acid (67127-91-7)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; methanol; water; for 14h; Reflux;

DOI:10.1016/j.bmcl.2011.10.119

upstream raw materials:

2,5-dihydroxybenzoic acid.

benzyl chloride

benzyl bromide

Downstream raw materials:

2,5-bis(benzyloxy)benzoic acid

2,5-bisbenzyloxybenzyl alcohol

2,5-bis(benzyloxy)benzoyl chloride

tert-butyl (4-{[3-(2,5-bis(benzyloxy)benzoylamino)propyl]-tert-butoxycarbonylamino}butyl)carbamate

Refernces

• 1、 Gardner, Richard Andrew,Kinkade, Rebecca,Wang, Chaojie,Phanstiel IV, Otto. "Total Synthesis of Petrobactin and Its Homologues as Potential Growth Stimuli for Marinobacter hydrocarbonoclasticus, an Oil-Degrading Bacteria". . p. 3530 - 3537. Retrieved 2007/10/03.
• 2、 Hill, Robert A.,Carter, Rachel H.,Staunton, James. "Biosynthesis of Fungal Metabolites. Terrein, a Metabolite of Aspergillus terreus Thom". . p. 2570 - 2576. Retrieved 2007/10/02.