ethyl 2-aminocyclohexanecarboxylate

Base Information

• Chemical Name: ethyl 2-aminocyclohexanecarboxylate
• CAS No.: 64162-07-8
• Molecular Formula: C9H17NO2
• Molecular Weight: 171.239
• Hs Code.: 2922499990
• Mol file: 64162-07-8.mol

Synonyms:(+-)-cis-2-amino-cyclohexane-carboxylic acid-(1)-ethyl ester;ethyl cis-2-aminocyclohexanecarboxylate;cis ethyl 2-aminocyclohexanecarboxylate;ethyl cis-2-aminocyclohexane-1-carboxylate;(+-)-cis-2-Amino-cyclohexan-carbonsaeure-(1)-aethylester;cis-2-Amino-cyclohexanecarboxylic acid ethyl ester;

Chemical Property of ethyl 2-aminocyclohexanecarboxylate

Chemical Property:

• Vapor Pressure: 0.0505mmHg at 25°C
• Boiling Point: 235.3oC at 760 mmHg
• Flash Point: 101.5oC
• PSA: 52.32000
• Density: 1.018g/cm3
• LogP: 1.76730
• Storage Temp.: Refrigerator, Under inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2-aminocyclohexanecarboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethyl 2-Aminocyclohexane-1-carboxylate can be used as anti-arrythmic agents.

Technology Process of ethyl 2-aminocyclohexanecarboxylate

There total 8 articles about ethyl 2-aminocyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-carbamoylcyclohex-3-enecarboxylic acid (1469-49-4,2028-12-8) → ethyl cis-2-amino-1-cyclohexanecarboxylate (1436-60-8,1436-61-9,24716-94-7,26849-62-7,64162-07-8,75197-07-8,115014-75-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / H₂ / 10percent Pt/C / ethanol / 760 Torr / Ambient temperature

2: 1.) bromine, NaOH; 2.) HCl / 1.) water, 75 deg C, 2 min; 2.) reflux, 3 h

With hydrogenchloride; sodium hydroxide; hydrogen; bromine; platinum on activated charcoal; In ethanol;

DOI:10.1016/S0040-4020(01)85926-3

Reference yield:

ethyl 2-aminocyclohex-1-ene-1-carboxylate (1128-00-3) → ethyl cis-2-amino-1-cyclohexanecarboxylate (1436-60-8,1436-61-9,24716-94-7,26849-62-7,64162-07-8,75197-07-8,115014-75-0)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In ethyl acetate; at 0 ℃; for 6h;

DOI:10.1002/adsc.201300982

Reference yield:

ethyl 2-aminocyclohex-1-ene-1-carboxylate (1128-00-3) → 2-amino-cyclohexanecarboxylic acid ethyl ester (64162-07-8)

Guidance literature:

With hydrogen; palladium on activated charcoal;

DOI:10.1021/jo01267a095

upstream raw materials:

ethyl 2-aminocyclohex-1-ene-1-carboxylate

anthranilic acid

ethanol

cis-1-carboxy-2-(aminocarboxyl)-2-cyclohexane

Downstream raw materials:

trans-2-amino-1-cyclohexylcarboxylic acid

2-benzoylamino-cyclohexanecarboxylic acid ethyl ester

2-aminocyclohexanecarboxamide

Salicylic acid