5-Nitrospiro[1,3-benzodioxole-2,1'-cyclohexane]

Base Information

• Chemical Name: 5-Nitrospiro[1,3-benzodioxole-2,1'-cyclohexane]
• CAS No.: 64179-40-4
• Molecular Formula: C12H13NO4
• Molecular Weight: 235.23600
• DSSTox Substance ID: DTXSID80351567
• Wikidata: Q82128077
• Mol file: 64179-40-4.mol

Synonyms:64179-40-4;5-nitrospiro[1,3-benzodioxole-2,1'-cyclohexane];5-Nitrospiro[benzo[d][1,3]dioxole-2,1'-cyclohexane];6-nitrospiro[1,3-benzodioxole-2,1'-cyclohexane];5-Nitrospiro[1,3-benzodioxole-2,1//'-cyclohexane];5-nitrospiro(1,3-benzodioxole-2,1'-cyclohexane);Cambridge id 6965807;Oprea1_504426;DTXSID80351567;MFCD01463454;STK734034;AKOS001061313;LS-07685;AE-562/12222262;SR-01000451445;SR-01000451445-1;Z56930800

Chemical Property of 5-Nitrospiro[1,3-benzodioxole-2,1'-cyclohexane]

Chemical Property:

• PSA: 64.28000
• LogP: 3.54960
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 235.08445790
• Heavy Atom Count: 17
• Complexity: 308

Purity/Quality:

99% ^*data from raw suppliers

5-Nitrospiro[1,3-benzodioxole-2,1'-cyclohexane] ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC2(CC1)OC3=C(O2)C=C(C=C3)[N+](=O)[O-]

Technology Process of 5-Nitrospiro[1,3-benzodioxole-2,1'-cyclohexane]

There total 4 articles about 5-Nitrospiro[1,3-benzodioxole-2,1'-cyclohexane] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.7%

spiro[benzo[d][1,3]dioxole-2,1'-cyclohexane] (182-55-8) → 5-nitrospiro<1,3-benzodioxole-2,1'-cyclohexane> (64179-40-4)

Guidance literature:

With nitric acid; In ethanol; at 0 ℃; for 0.25h;

DOI:10.1021/jm00159a029

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 5-nitrospiro<1,3-benzodioxole-2,1'-cyclohexane> (64179-40-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 36.2 percent / p-TsOH / toluene / 24 h / Heating

2: 80.7 percent / 60percent aq. HNO₃ / ethanol / 0.25 h / 0 °C

With nitric acid; toluene-4-sulfonic acid; In ethanol; toluene;

DOI:10.1021/jm00159a029

Reference yield:

benzene-1,2-diol (120-80-9,19481-10-8,37349-32-9) → 5-nitrospiro<1,3-benzodioxole-2,1'-cyclohexane> (64179-40-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 36.2 percent / p-TsOH / toluene / 24 h / Heating

2: 80.7 percent / 60percent aq. HNO₃ / ethanol / 0.25 h / 0 °C

With nitric acid; toluene-4-sulfonic acid; In ethanol; toluene;

DOI:10.1021/jm00159a029

upstream raw materials:

spiro[benzo[d][1,3]dioxole-2,1'-cyclohexane]

cyclohexanone

benzene-1,2-diol

Downstream raw materials:

5-aminospiro<1,3-benzodioxole-2,1'-cyclohexane>

3',4'-dihydroxy-N-methylacetanilide

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