Phosphonic acid, (2-oxo-1,2-diphenylethyl)-, diethyl ester

Base Information

• Chemical Name: Phosphonic acid, (2-oxo-1,2-diphenylethyl)-, diethyl ester
• CAS No.: 64196-48-1
• Molecular Formula: C18H21O4P
• Molecular Weight: 332.336
• DSSTox Substance ID: DTXSID80439415
• Nikkaji Number: J323.983G

Synonyms:64196-48-1;Phosphonic acid, (2-oxo-1,2-diphenylethyl)-, diethyl ester;DTXSID80439415;(1,2-Diphenyl-2-oxoethyl)phosphonic acid diethyl ester

Chemical Property of Phosphonic acid, (2-oxo-1,2-diphenylethyl)-, diethyl ester

Chemical Property:

• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 8
• Exact Mass: 332.11774614
• Heavy Atom Count: 23
• Complexity: 401

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOP(=O)(C(C1=CC=CC=C1)C(=O)C2=CC=CC=C2)OCC

Technology Process of Phosphonic acid, (2-oxo-1,2-diphenylethyl)-, diethyl ester

There total 12 articles about Phosphonic acid, (2-oxo-1,2-diphenylethyl)-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

phosphonic acid diethyl ester (762-04-9) + 2-diazo-1,2-diphenylethan-1-one (3469-17-8) → α-(diethoxyphosphinyl)-α-phenylacetophenone (64196-48-1)

Guidance literature:

copper acetylacetonate; In benzene; for 1h; Heating;

DOI:10.1055/s-1990-26924

Reference yield: 75.0%

iodobenzene (591-50-4) + diethyl benzoylmethylphosphonate (3453-00-7) → α-(diethoxyphosphinyl)-α-phenylacetophenone (64196-48-1)

Guidance literature:

With copper(l) iodide; caesium carbonate; L-proline; In dimethyl sulfoxide; at 70 ℃; for 24h; Inert atmosphere;

DOI:10.1002/adsc.201100605

Reference yield: 65.0%

diethyl phosphorylchloridite (589-57-1) + 2-hydroxy-2-phenylacetophenone (119-53-9,579-44-2) → α-(diethoxyphosphinyl)-α-phenylacetophenone (64196-48-1)

Guidance literature:

With iron(III) chloride; In hexane; at 0 - 20 ℃; for 48h;

DOI:10.1021/jo00264a023

upstream raw materials:

benzoic acid methyl ester

O,O-diethyl benzylphosphonate

diethyl phosphorylchloridite

2-hydroxy-2-phenylacetophenone

Downstream raw materials:

((1R,2S)-2-Hydroxy-1,2-diphenyl-ethyl)-phosphonic acid diethyl ester

((1R,2R)-2-Hydroxy-1,2-diphenyl-ethyl)-phosphonic acid diethyl ester

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