2-[4-(trifluoromethyl)phenyl]-1H-isoindole-1,3(2H)-dione

Base Information

Chemical Name:2-[4-(trifluoromethyl)phenyl]-1H-isoindole-1,3(2H)-dione
CAS No.:1555-31-3
Molecular Formula:C15H8 F3 N O2
Molecular Weight:291.229
Hs Code.:
Mol file:1555-31-3.mol

Synonyms:Phthalimide,N-(a,a,a-trifluoro-p-tolyl)- (6CI,8CI); NSC 517870

Suppliers and Price of 2-[4-(trifluoromethyl)phenyl]-1H-isoindole-1,3(2H)-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 2-[4-(trifluoromethyl)phenyl]-1H-isoindole-1,3(2H)-dione

Chemical Property:

Vapor Pressure:9.56E-07mmHg at 25°C
Boiling Point:404.3°Cat760mmHg
Flash Point:198.3°C
Density:1.454g/cm³

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-[4-(trifluoromethyl)phenyl]-1H-isoindole-1,3(2H)-dione

There total 6 articles about 2-[4-(trifluoromethyl)phenyl]-1H-isoindole-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 85-44-9
phthalic anhydride

: 455-14-1
4-trifluoromethylphenylamine

: 1555-31-3
2-(4-(trifluoromethyl)phenyl)isoindoline-1,3-dione

Guidance literature:: In N,N-dimethyl-formamide; for 24h; Reflux;
DOI:10.1021/cm202650u

Reference yield: 37.0%

: 136918-14-4,85-41-6
phthalimide

: 402-43-7
p-trifluoromethylphenyl bromide

: 762-04-9
phosphonic acid diethyl ester

: 1555-31-3
2-(4-(trifluoromethyl)phenyl)isoindoline-1,3-dione

: 77918-46-8
diethyl (4-(trifluoromethyl)phenyl)-phosphonate

Guidance literature:: With nickel(II) bromide trihydrate; tetraethylammonium hexafluorophosphate; caesium carbonate; 4,4'-di-tert-butyl-2,2'-bipyridine; In N,N-dimethyl acetamide; at 20 ℃; for 3h; Electrochemical reaction; Schlenk technique; Inert atmosphere;
DOI:10.1021/acs.orglett.9b02475

Reference yield:

: 136918-14-4,85-41-6
phthalimide

: 98-08-8
α,α,α-trifluorotoluene

: 1555-31-3
2-(4-(trifluoromethyl)phenyl)isoindoline-1,3-dione

: 314-81-8
2-[3-(trifluoromethyl)phenyl]-1H-isoindole-1,3(2H)-dione

Guidance literature:: With [bis(acetoxy)iodo]benzene; iodine; In dichloromethane; at 20 ℃; for 12h; Overall yield = 34percent; Overall yield = 19.7 mg; Irradiation;
DOI:10.1021/acs.orglett.0c00433