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4-Aminobenzotrifluoride 455-14-1 /manufacturer/low price/high quality/in stock
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Bosang 4-Aminobenzotrifluoride CAS NO.455-14-1
Cas No: 455-14-1
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high quality Teriflunomide intermediate 4-(Trifluoromethyl)aniline
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4-Aminobenzotrifluoride
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4-Aminotrifluorotoluene
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High quality 4-(Trifluoromethyl) Aniline supplier in China
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4-Aminobenzotrifluoride
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High Quality Oled CAS 455-14-1 Benzenamine,4-(trifluoromethyl)-
Cas No: 455-14-1
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier
Factory Supply 4-(Trifluoromethyl) Aniline
Cas No: 455-14-1
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Amadis Chemical offer CAS#455-14-1;CAT#A7166
Cas No: 455-14-1
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455-14-1 Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 54, p. 2873, 1989 DOI: 10.1021/jo00273a020

Uses

4-Substituted aniline derivatives exert special hematotoxicity on the red blood cells and induce leukocytosis.

Chemical Properties

clear colorless to yellow liquid

Definition

ChEBI: A substituted aniline that is a benzene ring substituted with an amino group at position 1 and a trifluoromethyl group at position 4.
InChI:InChI=1/C7H6F3N/c8-7(9,10)5-1-3-6(11)4-2-5/h1-4H,11H2

455-14-1 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma-Aldrich (PHR1568)    pharmaceutical secondary standard; traceable to USP, PhEur 455-14-1 PHR1568-200MG 1,437.35CNY Detail
Sigma-Aldrich (Y0000487)  LeflunomideimpurityA  European Pharmacopoeia (EP) Reference Standard 455-14-1 Y0000487 1,880.19CNY Detail
USP (1357045)  LeflunomideRelatedCompoundA  United States Pharmacopeia (USP) Reference Standard 455-14-1 1357045-100MG 13,525.20CNY Detail

455-14-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-trifluoromethylaniline

1.2 Other means of identification

Product number -
Other names 4-aminotrifluorotoluene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:455-14-1 SDS

455-14-1Synthetic route

p-nitrobenzotrifluoride
402-54-0

p-nitrobenzotrifluoride

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

Conditions
ConditionsYield
With Zr12(μ3-O)5[(μ3-O)CoCl]8[(μ2-O)2(μ3-O)CoCl]3Li3(triphenyldicarboxylate)9; hydrogen; sodium triethylborohydride In toluene at 110℃; under 30003 Torr; for 42h; Catalytic behavior; Inert atmosphere; Schlenk technique;100%
With hydrazine hydrate In ethanol at 40℃; for 0.5h;99%
With LaCu0.67Si1.33; hydrogen In isopropyl alcohol at 120℃; under 22502.3 Torr; for 54h; Autoclave;99%
4-(trifluoromethyl)phenylhydrazine
368-90-1

4-(trifluoromethyl)phenylhydrazine

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

Conditions
ConditionsYield
nickel In methanol for 1h; Heating / reflux;100%
With hydrogen; nickel In methanol at 20℃; under 3750.38 Torr; for 2h;75%
p-trifluoromethylphenyl bromide
402-43-7

p-trifluoromethylphenyl bromide

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

Conditions
ConditionsYield
With C24H32N2*ClCu; ammonia; potassium carbonate In 1-methyl-pyrrolidin-2-one; methanol at 90℃; under 5171.62 Torr; for 24h; Inert atmosphere;95%
With ammonium hydroxide; copper(l) iodide; potassium carbonate; 4R-4-hydroxyproline In dimethyl sulfoxide at 50℃; for 24h;91%
Stage #1: p-trifluoromethylphenyl bromide With bis(bis(trimethylsilyl)amido)zinc(II); tri-tert-butyl phosphine; lithium chloride; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran at 50℃; for 4h;
Stage #2: With hydrogenchloride In tetrahydrofuran; diethyl ether
90%
4-Iodobenzotrifluoride
455-13-0

4-Iodobenzotrifluoride

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

Conditions
ConditionsYield
With ammonium hydroxide; caesium carbonate In water for 1h; Reflux; Green chemistry;92%
With ammonium hydroxide; caesium carbonate In water for 1h; Catalytic behavior; Reflux;92%
With ammonium hydroxide; caesium carbonate In acetonitrile for 1h; Reflux; Green chemistry;91%
1-azido-4-(trifluoromethyl)benzene
5586-13-0

1-azido-4-(trifluoromethyl)benzene

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

Conditions
ConditionsYield
With water for 5h; Inert atmosphere; UV-irradiation; Sealed tube; chemoselective reaction;92%
With C36H44CuN8(1+)*BF4(1-) In water; toluene at 100℃; for 20h; Sealed tube; chemoselective reaction;64%
With sodium tetrahydroborate In methanol; water at 20℃; for 0.333333h; Green chemistry;> 99 %Chromat.
With sodium tetrahydroborate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2 In methanol; water at 20℃; for 0.166667h;
With sodium tetrahydroborate In water at 20℃; for 0.416667h; Green chemistry;> 99 %Chromat.
4-chlorobenzotrifluoride
98-56-6

4-chlorobenzotrifluoride

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

Conditions
ConditionsYield
Stage #1: 4-chlorobenzotrifluoride With bis(bis(trimethylsilyl)amido)zinc(II); tri-tert-butyl phosphine; lithium chloride; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran at 90℃; for 18h;
Stage #2: With hydrogenchloride In tetrahydrofuran; diethyl ether
88%
With ammonium hydroxide; potassium phosphate In dimethyl sulfoxide at 80℃; UV-irradiation;86%
With 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; ammonia; sodium t-butanolate In 1,4-dioxane at 110℃; Buchwald-Hartwig Coupling; Inert atmosphere; Glovebox;62%
4-trifluoromethylcyclohexanone oxime
75092-01-2

4-trifluoromethylcyclohexanone oxime

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

Conditions
ConditionsYield
With Pd(OH)x/LDH In N,N-dimethyl acetamide at 150℃; for 1h; Schlenk technique; Inert atmosphere;85%
4-(trifluromethyl)acetanilide
349-97-3

4-(trifluromethyl)acetanilide

A

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

B

(4-trifluoromethylphenyl)ethylamine

(4-trifluoromethylphenyl)ethylamine

Conditions
ConditionsYield
With [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); formic acid; bis(trifluoromethanesulfonyl)amide; triethylamine; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In dibutyl ether at 130℃; for 24h;A 79%
B n/a
4-trifluoromethylphenylboronic acid
128796-39-4

4-trifluoromethylphenylboronic acid

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

Conditions
ConditionsYield
With O-(2,4-dinitrophenyl)hydroxylamine In toluene at 80℃; for 96h; Inert atmosphere;78%
With copper(I) oxide; ammonium hydroxide; oxygen; sodium hydroxide In water at 25℃; for 24h;70%
With sodium hydroxide; hydroxylamine-O-sulfonic acid In acetonitrile at 20℃; for 5h; Reflux;57%
4-(triethylsiloxy)-4-(trifluoromethyl)-2,5-cyclohexadien-1-one
120120-28-7

4-(triethylsiloxy)-4-(trifluoromethyl)-2,5-cyclohexadien-1-one

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

Conditions
ConditionsYield
With glycine ethyl ester hydrochloride; sodium hydrogencarbonate In ethanol for 6h; Heating;73%
(trifluoromethyl)trimethylsilane
81290-20-2

(trifluoromethyl)trimethylsilane

4-bromo-aniline
106-40-1

4-bromo-aniline

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

Conditions
ConditionsYield
With bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; sodium dodecyl-sulfate; cesium fluoride In toluene at 110℃; for 12h; Inert atmosphere;71%
5-((4-(trifluoromethyl)phenyl)imino)-5H-5λ4-dibenzo[b,d]thiophene 5-oxide

5-((4-(trifluoromethyl)phenyl)imino)-5H-5λ4-dibenzo[b,d]thiophene 5-oxide

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

Conditions
ConditionsYield
With 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane In toluene at 100℃; Sealed tube;69%
Togni's reagent II
887144-94-7

Togni's reagent II

aniline
62-53-3

aniline

A

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

B

2-(trifluoromethyl)benzenamine
88-17-5

2-(trifluoromethyl)benzenamine

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 75℃; for 6h; Schlenk technique; Inert atmosphere;A 20%
B 66%
With potassium carbonate; nickel(II) hydroxide In dimethyl sulfoxide at 35℃; for 2h; Reagent/catalyst; Solvent; Temperature; Overall yield = 89 %;A 20%
B 61%
With potassium carbonate; nickel(II) hydroxide In dimethyl sulfoxide at 35℃; for 2h; Reagent/catalyst; Solvent; Inert atmosphere;A 20%
B 49%
4-(trifluromethyl)acetanilide
349-97-3

4-(trifluromethyl)acetanilide

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

Conditions
ConditionsYield
With [RuCl2(2-(diphenylphosphino)-N-((6-((diphenylphosphino)methyl)pyridin-2-yl)methyl)ethan-1-amine)]; potassium tert-butylate; hydrogen In tetrahydrofuran at 100℃; under 37503.8 Torr; for 20h; Catalytic behavior; Autoclave; chemoselective reaction;65%
2,5-dimethyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrrole
570-05-8

2,5-dimethyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrrole

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

Conditions
ConditionsYield
With trifluoroacetic acid for 48h; Reflux;56%
iodotrifluoromethane
2314-97-8

iodotrifluoromethane

aniline
62-53-3

aniline

A

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

B

2-(trifluoromethyl)benzenamine
88-17-5

2-(trifluoromethyl)benzenamine

Conditions
ConditionsYield
With fac-tris(2-phenylpyridinato-N,C2')iridium(III); potassium carbonate In 1,2-dichloro-ethane at 20℃; for 24h; Inert atmosphere; Schlenk technique; Irradiation; regioselective reaction;A 34%
B 54%
With sulfuric acid; dihydrogen peroxide; iron(II) sulfate; dimethyl sulfoxide In water at 40 - 50℃; for 0.333333h;A 7.2 %Spectr.
B 8.5 %Spectr.
With dihydrogen peroxide; iron(II) sulfate In water; dimethyl sulfoxideA 13 %Spectr.
B 22 %Spectr.
tert-butyl 2-(4-methoxyphenyl)-1-(4-(trifluoromethyl)phenyl)hydrazine-1-carboxylate

tert-butyl 2-(4-methoxyphenyl)-1-(4-(trifluoromethyl)phenyl)hydrazine-1-carboxylate

A

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

B

4-methoxy-aniline
104-94-9

4-methoxy-aniline

Conditions
ConditionsYield
With hydrogenchloride In ethanol for 2h; Inert atmosphere; Reflux; regioselective reaction;A 24%
B 54%
[1-(3,4-Dimethoxy-phenyl)-meth-(Z)-ylidene]-(4-trifluoromethyl-phenyl)-amine

[1-(3,4-Dimethoxy-phenyl)-meth-(Z)-ylidene]-(4-trifluoromethyl-phenyl)-amine

A

8,9-dimethoxy-2-(trifluoromethyl)phenanthridine

8,9-dimethoxy-2-(trifluoromethyl)phenanthridine

B

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

C

3,4-dimethoxy-benzaldehyde
120-14-9

3,4-dimethoxy-benzaldehyde

Conditions
ConditionsYield
With vanadium(V) oxytrifluoride; trifluoroacetic acid In dichloromethane; ethyl acetate at -30℃; for 0.166667h;A 52%
B 75 mg
C 220 mg
2,3,7,8-tetrafluoro-S-(trifluoromethyl)dibenzothiophenium trifluoromethanesulfonate

2,3,7,8-tetrafluoro-S-(trifluoromethyl)dibenzothiophenium trifluoromethanesulfonate

aniline
62-53-3

aniline

A

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

B

2-(trifluoromethyl)benzenamine
88-17-5

2-(trifluoromethyl)benzenamine

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 30℃; for 3h; Inert atmosphere;A 23%
B 44%
3,7-dinitro-Se-(trifluoromethyl)dibenzoselenophenium triflate
129922-39-0

3,7-dinitro-Se-(trifluoromethyl)dibenzoselenophenium triflate

aniline
62-53-3

aniline

A

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

B

2-(trifluoromethyl)benzenamine
88-17-5

2-(trifluoromethyl)benzenamine

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 0.5h; Ambient temperature; Title compound not separated from byproducts;A 16 % Spectr.
B 39%
In N,N-dimethyl-formamide for 0.5h; Ambient temperature; Title compound not separated from byproducts;A 16 % Spectr.
B 39 % Spectr.
Umemoto's reagent
129946-88-9

Umemoto's reagent

aniline
62-53-3

aniline

A

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

B

2-(trifluoromethyl)benzenamine
88-17-5

2-(trifluoromethyl)benzenamine

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 80℃; for 5h; Title compound not separated from byproducts;A 15%
B 37%
In N,N-dimethyl-formamide at 80℃; for 7h;A 18%
B 39 % Spectr.
In N,N-dimethyl-formamide at 30℃; for 3h; Inert atmosphere;A 2%
B 5%
aniline
62-53-3

aniline

S-(Trifluoromethyl)-7-nitrodibenzothiophenium-3-sulfonate
160656-66-6

S-(Trifluoromethyl)-7-nitrodibenzothiophenium-3-sulfonate

A

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

B

2-(trifluoromethyl)benzenamine
88-17-5

2-(trifluoromethyl)benzenamine

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 80℃; for 0.5h;A 18 % Spectr.
B 37%
In N,N-dimethyl-formamide at 80℃; for 0.5h;A 18%
B 37 % Spectr.
In N,N-dimethyl-formamide at 80℃; for 0.5h; Product distribution; other temperature;
tert-butyl 2-(2,4,6-trimethylphenyl)-1-(4-trifluoromethylphenyl)hydrazinecarboxylate

tert-butyl 2-(2,4,6-trimethylphenyl)-1-(4-trifluoromethylphenyl)hydrazinecarboxylate

A

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

B

1-mesityl-2-[4-(trifluoromethyl)phenyl]diazene

1-mesityl-2-[4-(trifluoromethyl)phenyl]diazene

C

2,4,6-trimethylaniline
88-05-1

2,4,6-trimethylaniline

Conditions
ConditionsYield
With hydrogenchloride In ethanol for 2h; Inert atmosphere; Reflux; Overall yield = 65 %; regioselective reaction;A n/a
B 37%
C n/a
2,6-difluoro-S-(trifluoromethyl)dibenzothiophenium trifluoromethanesulfonate

2,6-difluoro-S-(trifluoromethyl)dibenzothiophenium trifluoromethanesulfonate

aniline
62-53-3

aniline

A

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

B

2-(trifluoromethyl)benzenamine
88-17-5

2-(trifluoromethyl)benzenamine

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 30℃; for 3h; Inert atmosphere;A 17%
B 37%
Bromotrifluoromethane
75-63-8

Bromotrifluoromethane

aniline
62-53-3

aniline

A

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

B

2-(trifluoromethyl)benzenamine
88-17-5

2-(trifluoromethyl)benzenamine

Conditions
ConditionsYield
With α-picoline; sodium metabisulfite; sulfur dioxide; zinc In N,N-dimethyl-formamide at 20℃; under 2250.2 - 3750.3 Torr; for 2h; Product distribution; other alkylating reagents, other method, other pressure, temp.; various substrates;A 20%
B 36%
With α-picoline; sodium metabisulfite; sulfur dioxide; zinc In N,N-dimethyl-formamide at 20℃; under 2250.2 - 3750.3 Torr; for 2h; also with NaS2O4;A 20%
B 36%
With sulfur dioxide; zinc In N,N-dimethyl-formamide under 2250.2 - 3750.3 Torr; for 2h; Ambient temperature;A 20%
B 36%
1,2-bis(4-(trifluoromethyl)phenyl)hydrazine
740-69-2

1,2-bis(4-(trifluoromethyl)phenyl)hydrazine

β-naphthol
135-19-3

β-naphthol

A

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

B

1-(4-(trifluoromethyl)phenylamino)naphthalen-2-ol

1-(4-(trifluoromethyl)phenylamino)naphthalen-2-ol

Conditions
ConditionsYield
In neat (no solvent) at 120℃; Inert atmosphere;A n/a
B 34%
4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

Conditions
ConditionsYield
Stage #1: 4-trifluoromethylbenzoic acid With trifluorormethanesulfonic acid; trimethylsilylazide In chloroform at 90℃; for 0.0583333h; Schmidt Reaction; Flow reactor;
Stage #2: With water In methanol; chloroform at 20℃; Schmidt Reaction; Flow reactor;
24%
tert-butyl 2-(2,6-dimethylphenyl)-1-(4-(trifluoromethyl)phenyl)hydrazinecarboxylate
1616514-64-7

tert-butyl 2-(2,6-dimethylphenyl)-1-(4-(trifluoromethyl)phenyl)hydrazinecarboxylate

A

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

B

3′,5′-dimethyl-5-trifluoromethyl-1,1′-biphenyl-2,4′-diamine
1616514-72-7

3′,5′-dimethyl-5-trifluoromethyl-1,1′-biphenyl-2,4′-diamine

C

3,5-dimethyl-N1-[4-(trifluoromethyl)phenyl]benzene-1,4-diamine
1616514-78-3

3,5-dimethyl-N1-[4-(trifluoromethyl)phenyl]benzene-1,4-diamine

D

2,6-Dimethyl-4'-(trifluoromethyl)azobenzene
150370-02-8

2,6-Dimethyl-4'-(trifluoromethyl)azobenzene

E

2,6-dimethylaniline
87-62-7

2,6-dimethylaniline

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water at 20℃; for 2h; Inert atmosphere; Reflux;A 9%
B 21%
C 18%
D 10%
E 6%
With hydrogenchloride In ethanol for 2h; Inert atmosphere; Reflux; Overall yield = 58 %; regioselective reaction;A 9%
B 21%
C 18%
D 10%
E 6%
tert-butyl 2-(2-ethyl-6-methylphenyl)-1-(4-(trifluoromethyl)phenyl)hydrazinecarboxylate
1616514-65-8

tert-butyl 2-(2-ethyl-6-methylphenyl)-1-(4-(trifluoromethyl)phenyl)hydrazinecarboxylate

A

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

B

6-ethyl-o-toluidine
24549-06-2

6-ethyl-o-toluidine

C

3′-ethyl-5′-methyl-5-trifluoromethyl-1,1′-biphenyl-2,4′-diamine
1616514-73-8

3′-ethyl-5′-methyl-5-trifluoromethyl-1,1′-biphenyl-2,4′-diamine

D

3-ethyl-5-methyl-N1-[4-(trifluoromethyl)phenyl]benzene-1,4-diamine
1616514-79-4

3-ethyl-5-methyl-N1-[4-(trifluoromethyl)phenyl]benzene-1,4-diamine

E

1-(2-ethyl-6-methylphenyl)-2-(4-(trifluoromethyl)phenyl)diazene
1616514-85-2

1-(2-ethyl-6-methylphenyl)-2-(4-(trifluoromethyl)phenyl)diazene

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water at 20℃; for 2h; Inert atmosphere; Reflux;A 10%
B 6%
C 10%
D 18%
E 12%
With hydrogenchloride In ethanol for 2h; Inert atmosphere; Reflux; Overall yield = 50 %; regioselective reaction;A 10%
B 6%
C 10%
D 18%
E 12%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

Ethyl oxalyl chloride
4755-77-5

Ethyl oxalyl chloride

ethyl 2-oxo-2-((4-(trifluoromethyl)phenyl)amino)acetate
69066-00-8

ethyl 2-oxo-2-((4-(trifluoromethyl)phenyl)amino)acetate

Conditions
ConditionsYield
With sodium hydrogencarbonate In dichloromethane at 0 - 20℃; for 8h;100%
With triethylamine In tetrahydrofuran at 20℃;99%
With pyridine In dichloromethane at 0 - 20℃; for 43h; Reflux; Inert atmosphere; Schlenk technique;96%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

2-iodo-4-(trifluoromethyl)aniline
163444-17-5

2-iodo-4-(trifluoromethyl)aniline

Conditions
ConditionsYield
With N,N,N-trimethylbenzenemethanaminium dichloroiodate; calcium carbonate In methanol; dichloromethane at 20℃; for 2h;100%
With Iodine monochloride In methanol; dichloromethane at 0 - 20℃;97%
With Iodine monochloride In methanol; dichloromethane at 0 - 20℃; for 1h;97%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

acetic anhydride
108-24-7

acetic anhydride

4-(trifluromethyl)acetanilide
349-97-3

4-(trifluromethyl)acetanilide

Conditions
ConditionsYield
In dichloromethane at 20℃; Inert atmosphere;100%
In dichloromethane; water at 25℃; for 1h; Temperature;99.3%
With pyridine at 0 - 20℃; for 0.5h;99%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

1-azido-4-(trifluoromethyl)benzene
5586-13-0

1-azido-4-(trifluoromethyl)benzene

Conditions
ConditionsYield
With tert.-butylnitrite; trimethylsilylazide In acetonitrile at 20℃; for 1h; Inert atmosphere;100%
Stage #1: 4-trifluoromethylphenylamine With hydrogenchloride; sodium nitrite In water at 0℃; for 2h;
Stage #2: With sodium azide In water at 0 - 20℃;
95%
Stage #1: 4-trifluoromethylphenylamine With hydrogenchloride; sodium nitrite In water at 0℃; for 2h;
Stage #2: With sodium azide In water at 0℃; for 2h;
95%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

benzoyl chloride
98-88-4

benzoyl chloride

N-(4-(trifluoromethyl)phenyl)benzamide
350-98-1

N-(4-(trifluoromethyl)phenyl)benzamide

Conditions
ConditionsYield
With triethylamine In dichloromethane for 2h;100%
With dmap In dichloromethane at 20℃; Inert atmosphere;91%
With triethylamine In dichloromethane at 0 - 40℃; Inert atmosphere;75%
furfural
98-01-1

furfural

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

1-(furan-2-yl)-N-(4-(trifluoromethyl)phenyl)methanimine
325139-72-8

1-(furan-2-yl)-N-(4-(trifluoromethyl)phenyl)methanimine

Conditions
ConditionsYield
With toluene-4-sulfonic acid In diethyl ether at 20℃; Molecular sieve; Inert atmosphere;100%
In benzene at 20℃; for 20h;70%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

5-triethylsilylfuran-2-carbaldehyde
13529-12-9

5-triethylsilylfuran-2-carbaldehyde

N-(5-triethylsilyl-2-furylmethylidene)-4-trifluoromethylaniline

N-(5-triethylsilyl-2-furylmethylidene)-4-trifluoromethylaniline

Conditions
ConditionsYield
With 4 A molecular sieve In benzene at 20℃; for 20h;100%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

4-methyl-N-(4-(trifluoromethyl)phenyl)benzenesulfonamide

4-methyl-N-(4-(trifluoromethyl)phenyl)benzenesulfonamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 4℃;100%
With pyridine In dichloromethane at 20℃; for 24h;98%
for 0.1h; microwave irradiation;92%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

3,4-dihydro-4-oxo-3-(2-chloro-3-pyridyl)-2-quinazolinecarbothioic acid S-p-tolyl ester
830324-69-1

3,4-dihydro-4-oxo-3-(2-chloro-3-pyridyl)-2-quinazolinecarbothioic acid S-p-tolyl ester

3-(2-chloro-pyridin-3-yl)-4-oxo-3,4-dihydro-quinazoline-2-carboxylic acid (4-trifluoromethyl-phenyl)-amide
830324-75-9

3-(2-chloro-pyridin-3-yl)-4-oxo-3,4-dihydro-quinazoline-2-carboxylic acid (4-trifluoromethyl-phenyl)-amide

Conditions
ConditionsYield
With silver trifluoroacetate In tetrahydrofuran; toluene at 60℃; for 1.5h;100%
pyridine-4-carbaldehyde
872-85-5

pyridine-4-carbaldehyde

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

C13H9F3N2

C13H9F3N2

Conditions
ConditionsYield
With magnesium sulfate In dichloromethane at 20℃; for 12h;100%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

potassium thioacyanate
333-20-0

potassium thioacyanate

1-(4-(trifluoromethyl)phenyl)thiourea
1736-72-7

1-(4-(trifluoromethyl)phenyl)thiourea

Conditions
ConditionsYield
With hydrogenchloride In water Heating / reflux;100%
(3R)-5-methoxy-3-[(trifluoroacetyl)amino]chromane-8-sulfonyl chloride
916222-27-0

(3R)-5-methoxy-3-[(trifluoroacetyl)amino]chromane-8-sulfonyl chloride

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

2,2,2-trifluoro-N-[(3R)-5-methoxy-8-({[4-(trifluoromethyl)phenyl]amino}sulfonyl)-3,4-dihydro-2H-chromen-3-yl]acetamide
916223-31-9

2,2,2-trifluoro-N-[(3R)-5-methoxy-8-({[4-(trifluoromethyl)phenyl]amino}sulfonyl)-3,4-dihydro-2H-chromen-3-yl]acetamide

Conditions
ConditionsYield
With pyridine In dichloromethane for 8h;100%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

propionaldehyde
123-38-6

propionaldehyde

N-propyl-4-(trifluoromethyl)benzenamine
190843-72-2

N-propyl-4-(trifluoromethyl)benzenamine

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 18℃; for 0.0833333h; Solvent; Green chemistry;100%
2,6-Pyridinedicarboxaldehyde
5431-44-7

2,6-Pyridinedicarboxaldehyde

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

C21H13F6N3

C21H13F6N3

Conditions
ConditionsYield
In dichloromethane for 4h; Molecular sieve;100%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

ortho-toluoyl chloride
933-88-0

ortho-toluoyl chloride

2-methyl-N-(4-(trifluoromethyl)phenyl)benzamide

2-methyl-N-(4-(trifluoromethyl)phenyl)benzamide

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 0 - 20℃; for 3h;100%
4-chloro-5-bromopyrimidine
56181-39-6

4-chloro-5-bromopyrimidine

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

C11H7BrF3N3

C11H7BrF3N3

Conditions
ConditionsYield
With p-toluenesulfonic acid monohydrate In 1-methyl-pyrrolidin-2-one at 60℃; for 2h;100%
With toluene-4-sulfonic acid In 1-methyl-pyrrolidin-2-one at 60℃; for 2h;51%
furfural
98-01-1

furfural

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

(E)-1-(furan-2-yl)-N-(4-(trifluoromethyl)phenyl)methanimine
1185039-73-9

(E)-1-(furan-2-yl)-N-(4-(trifluoromethyl)phenyl)methanimine

Conditions
ConditionsYield
In toluene Inert atmosphere; Reflux; Dean-Stark;100%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

7-isoselenocyanato-4-methyl-2H-chromen-2-one

7-isoselenocyanato-4-methyl-2H-chromen-2-one

N-(4-methyl-2-oxo-2H-chromen-7-yl)-N'-(4-trifluoromethyl)selenourea

N-(4-methyl-2-oxo-2H-chromen-7-yl)-N'-(4-trifluoromethyl)selenourea

Conditions
ConditionsYield
In tetrahydrofuran at 40℃; for 2h; Inert atmosphere; Darkness;100%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

benzaldehyde
100-52-7

benzaldehyde

N-benzylidene-4-(trifluoromethyl)aniline
351-98-4

N-benzylidene-4-(trifluoromethyl)aniline

Conditions
ConditionsYield
at 50℃; Condensation;99.1%
In water at 20℃; for 12h; Inert atmosphere;95%
In toluene for 0.5h; Heating;84%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

4-nitro-benzoyl chloride
122-04-3

4-nitro-benzoyl chloride

4-nitro-N-(4-(trifluoromethyl)phenyl)benzamide
7607-41-2

4-nitro-N-(4-(trifluoromethyl)phenyl)benzamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 2h; Inert atmosphere;99%
With pyridine for 4h; Heating;95%
With pyridine at 20℃; Inert atmosphere; Reflux;95%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

potassium thioacyanate
333-20-0

potassium thioacyanate

2-amino-6-trifluoromethyl-1,3-benzothiazole
777-12-8

2-amino-6-trifluoromethyl-1,3-benzothiazole

Conditions
ConditionsYield
With sodium iodide dichloride at 70℃; for 2h;99%
With 6-methylbenzothiazol-2-ylamine; N,N,N,N,-tetramethylethylenediamine; oxygen; copper(II) bis(trifluoromethanesulfonate) In dimethyl sulfoxide at 100℃; for 24h; regioselective reaction;80%
With bromine In acetic acid for 24h;20%
With bromine; acetic acid for 21h; Ambient temperature;
With bromine In acetic acid Cooling with ice;
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

acetonitrile
75-05-8

acetonitrile

(4-trifluoromethylphenyl)ethylamine

(4-trifluoromethylphenyl)ethylamine

Conditions
ConditionsYield
With ammonium acetate; hydrogen; palladium on activated charcoal In methanol at 20℃; for 24h;99%
With palladium 10% on activated carbon; hydrogen; acetic acid In methanol at 20℃; under 760.051 Torr; for 18h;99%
4-(chlorocarbonyl)pyridine
14254-57-0

4-(chlorocarbonyl)pyridine

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

N-[4-(trifluoromethyl)phenyl]-4-pyridinecarboxamide

N-[4-(trifluoromethyl)phenyl]-4-pyridinecarboxamide

Conditions
ConditionsYield
With sodium hydrogencarbonate In tetrahydrofuran at 0 - 65℃; for 1.58333h;99%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

Cp*Ni(PEt3)S(OMe)
198903-09-2

Cp*Ni(PEt3)S(OMe)

Cp*Ni(PEt3)NHC6H4(p-CF3)
198903-17-2

Cp*Ni(PEt3)NHC6H4(p-CF3)

Conditions
ConditionsYield
In diethyl ether inert atmosphere; stirring (10 min); removal of volatile materials (vac.), crystn. (pentane);99%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

5-nitrosalicylic acid
96-97-9

5-nitrosalicylic acid

2-hydroxy-5-nitro-N-[4-(trifluoromethyl)phenyl]benzamide
198774-77-5

2-hydroxy-5-nitro-N-[4-(trifluoromethyl)phenyl]benzamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃;99%
With phosphorus trichloride Microwave irradiation; Reflux;76%
With phosphorus trichloride In 5,5-dimethyl-1,3-cyclohexadiene at 120℃; for 3h; Inert atmosphere;66.2%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;
3-Chloropropyl isocyanate
13010-19-0

3-Chloropropyl isocyanate

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

1-(3-chloropropyl)-3-(4-(trifluoromethyl)phenyl)urea
1422166-44-6

1-(3-chloropropyl)-3-(4-(trifluoromethyl)phenyl)urea

Conditions
ConditionsYield
In dichloromethane at 0 - 20℃;99%
In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran at 20℃; for 72h;87%
In dichloromethane at 20℃; for 72h;
In dichloromethane at 20℃;
4,7-dichloroquinoline
86-98-6

4,7-dichloroquinoline

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

4-((4-trifluoromethylphenyl)amino)-7-chloroquinolinium chloride

4-((4-trifluoromethylphenyl)amino)-7-chloroquinolinium chloride

Conditions
ConditionsYield
In ethanol Reflux;99%
tetrafluoroboric acid

tetrafluoroboric acid

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

p-(trifluoromethyl)benzenediazonium tetrafluoroborate

p-(trifluoromethyl)benzenediazonium tetrafluoroborate

Conditions
ConditionsYield
Stage #1: tetrafluoroboric acid; 4-trifluoromethylphenylamine In water at 0℃; for 0.166667h;
Stage #2: With sodium nitrite In water at 0℃; for 0.283333h;
99%
With isopentyl nitrite In ethanol; water at -20 - 20℃; for 1h; Inert atmosphere;77%
With sodium nitrite In water at 0℃; for 0.5h;70%
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