4,5-Bis(bromomethyl)acridine

Base Information

• Chemical Name: 4,5-Bis(bromomethyl)acridine
• CAS No.: 643742-28-3
• Molecular Formula: C15H11Br2N
• Molecular Weight: 365.067
• DSSTox Substance ID: DTXSID10457107
• Nikkaji Number: J2.382.643G
• Wikidata: Q82279822
• Mol file: 643742-28-3.mol

Synonyms:4,5-bis(bromomethyl)acridine;643742-28-3;4,5-dibromomethyl-acridine;SCHEMBL1567897;DTXSID10457107;AKOS027380812

Chemical Property of 4,5-Bis(bromomethyl)acridine

Chemical Property:

• PSA: 12.89000
• LogP: 5.17780
• XLogP3: 4.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 364.92378
• Heavy Atom Count: 18
• Complexity: 258

Purity/Quality:

98.5% ^*data from raw suppliers

4,5-BIS(BROMOMETHYL)ACRIDINE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=CC3=C(C(=CC=C3)CBr)N=C2C(=C1)CBr

Technology Process of 4,5-Bis(bromomethyl)acridine

There total 3 articles about 4,5-Bis(bromomethyl)acridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.2%

acridine (260-94-6) + bromethyl methyl ether (13057-17-5) → 4,5-bis-bromomethylacridine (643742-28-3)

Guidance literature:

With sulfuric acid; at 50 ℃; for 12h; Inert atmosphere;

DOI:10.3987/COM-08-11346

Reference yield:

acridine (260-94-6) → 4,5-bis-bromomethylacridine (643742-28-3)

Guidance literature:

With sulfuric acid;

DOI:10.1039/c3nj01341c

Reference yield:

acridine (260-94-6) + bis(bromomethyl) ether (4497-29-4) → 4,5-bis-bromomethylacridine (643742-28-3)

Guidance literature:

With sulfuric acid; at 50 ℃;

DOI:10.1039/c4dt02813a

upstream raw materials:

acridine

bromethyl methyl ether

bis(bromomethyl) ether

Downstream raw materials:

4,5-bis(di-iso-propylphosphinomethyl)acridine

4,5-bis(benzyloxymethyl)acridine

4,5-bis[(dicyclohexylphosphanyl)methyl]acridine

3,6,9,12-tosyl-1-(6,7)-acridina-3,6,9,12-tetraazatridecaphane