1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-8-phenyl-

Base Information

• Chemical Name: 1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-8-phenyl-
• CAS No.: 6439-88-9
• Molecular Formula: C14H14N4O2
• Molecular Weight: 270.291
• Mol file: 6439-88-9.mol

Synonyms:

Chemical Property of 1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-8-phenyl-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-8-phenyl-

There total 35 articles about 1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-8-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

bromobenzene (108-86-1,52753-63-6) + 3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione (58-08-2,138455-22-8,95789-13-2) → 1,3,7-trimethyl-8-phenylxanthine (6439-88-9)

Guidance literature:

With potassium phosphate; palladium diacetate; Trimethylacetic acid; In N,N-dimethyl-formamide; at 20 - 120 ℃; for 7.16667h; Inert atmosphere;

DOI:10.1002/chem.200802001

Reference yield: 93.0%

3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione (58-08-2,138455-22-8,95789-13-2) + sodium benzenesulfonate (873-55-2) → 1,3,7-trimethyl-8-phenylxanthine (6439-88-9)

Guidance literature:

With bis(benzonitrile)palladium(II) dichloride; copper diacetate; In 1,4-dioxane; dimethyl sulfoxide; at 20 - 110 ℃; for 24.08h; Inert atmosphere;

DOI:10.1002/chem.201102644

Reference yield: 90.0%

1,3,7-trimethyl-8-(phenylthio)-1H-purine-2,6(3H,7H)-dione (130332-80-8) + phenylboronic acid (98-80-6) → 1,3,7-trimethyl-8-phenylxanthine (6439-88-9)

Guidance literature:

With copper(I) thiophene-2-carboxylate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; at 60 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.tetlet.2013.08.097

upstream raw materials:

1-methyl-8-phenylxanthine

dimethyl sulfate

1,7-dimethyl-8-phenyl-3,7-dihydro-purine-2,6-dione

(E)-1,2-diphenyl-ethene

Refernces

• 1、 Ma, Xiaodong,Zhang, Guozhu. "Visible Light-Induced Copper-Catalyzed C—H Arylation of Benzoxazoles?". supporting information. p. 1299 - 1303. Retrieved 2020/08/05.
• 2、 Shimizu, Maki,Hayama, Noboru,Kimachi, Tetsutaro,Inamoto, Kiyofumi. "Copper-Catalyzed Intramolecular C-H Amination: A New Entry to Substituted Xanthine Derivatives". . p. 4183 - 4190. Retrieved 2017/09/12.