1-Piperidinecarboxylic acid, 4-[2-[[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]methylamino]-2-oxoeth yl]-4-(4-fluorophenyl)-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: 1-Piperidinecarboxylic acid, 4-[2-[[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]methylamino]-2-oxoeth yl]-4-(4-fluorophenyl)-, 1,1-dimethylethyl ester
• CAS No.: 644982-31-0
• Molecular Formula: C29H33F7N2O3
• Molecular Weight: 590.581
• Mol file: 644982-31-0.mol

Synonyms:

Chemical Property of 1-Piperidinecarboxylic acid, 4-[2-[[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]methylamino]-2-oxoeth yl]-4-(4-fluorophenyl)-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 4-[2-[[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]methylamino]-2-oxoeth yl]-4-(4-fluorophenyl)-, 1,1-dimethylethyl ester

There total 1 articles about 1-Piperidinecarboxylic acid, 4-[2-[[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]methylamino]-2-oxoeth yl]-4-(4-fluorophenyl)-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[1-{[(1,1-dimethylethyl)-oxy]-carbonyl}-4-(4-fluorophenyl)-4-piperidinyl]-acetic acid (644981-80-6) + (S)-1-(3,5-bis(trifluoromethyl)phenyl)-N-methylethanamine (511256-36-3) → 4-({[1-(S)-1-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-methyl-carbamoyl}-methyl)-4-(4-fluoro-phenyl)-piperidine-1-carboxylic acid tert-butyl ester (644982-31-0)

Guidance literature:

[1-{[(1,1-dimethylethyl)-oxy]-carbonyl}-4-(4-fluorophenyl)-4-piperidinyl]-acetic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); for 0.25h;

(S)-1-(3,5-bis(trifluoromethyl)phenyl)-N-methylethanamine; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 48h;

Reference yield:

4-({[1-(S)-1-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-methyl-carbamoyl}-methyl)-4-(4-fluoro-phenyl)-piperidine-1-carboxylic acid tert-butyl ester (644982-31-0) → N-[1-(S)-1-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-2-[4-(4-fluoro-phenyl)-piperidin-4-yl]-N-methyl-acetamide

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 2h;

upstream raw materials:

[1-{[(1,1-dimethylethyl)-oxy]-carbonyl}-4-(4-fluorophenyl)-4-piperidinyl]-acetic acid

(S)-1-(3,5-bis(trifluoromethyl)phenyl)-N-methylethanamine