Depramine

Base Information

• Chemical Name: Depramine
• CAS No.: 303-54-8
• Molecular Formula: C₁₉H₂₂N₂
• Molecular Weight: 278.397
• Hs Code.: 2933994600
• UNII: 77C3T28736
• DSSTox Substance ID: DTXSID90184388
• Nikkaji Number: J8.631B
• Wikipedia: Depramine
• Wikidata: Q5260816
• NCI Thesaurus Code: C78014
• ChEMBL ID: CHEMBL2104158
• Mol file: 303-54-8.mol

Synonyms:10,11-dehydroimipramine;10,11-dehydroimipramine fumarate (1:1);10,11-dehydroimipramine fumarate (2:1);10,11-dehydroimipramine hydrochloride;CIBA G-31406;depramine

Chemical Property of Depramine

Chemical Property:

• Vapor Pressure: 4.64E-07mmHg at 25°C
• Melting Point: 56-57 °C(Solv: pentane (109-66-0))
• Refractive Index: 1.8676 (estimate)
• Boiling Point: 413.9°Cat760mmHg
• PKA: 9.47±0.28(Predicted)
• Flash Point: 185.9°C
• PSA: 6.48000
• Density: 1.06g/cm³
• LogP: 4.32520
• XLogP3: 5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 278.178298710
• Heavy Atom Count: 21
• Complexity: 324

Purity/Quality:

98%min ^*data from raw suppliers

DEPRAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CCCN1C2=CC=CC=C2C=CC3=CC=CC=C31
• Uses: [Name previously used: Balipramine. Depramine is an antidepressant.

Technology Process of Depramine

There total 3 articles about Depramine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 3-(5H-dibenzo[b,f]azepin-5-yl)propan-1-amine (2064-34-8) → imipramine (303-54-8)

Guidance literature:

With formic acid; In water; at 100 ℃; for 1h; Microwave irradiation;

DOI:10.1021/acschemneuro.8b00242

Reference yield:

dibenzoazepine (256-96-2) + 3-(Dimethylamino)propyl chloride (109-54-6) → imipramine (303-54-8)

Guidance literature:

With sodium hydroxide; potassium carbonate; Yield given. Multistep reaction; DMSO 1.) room temp., 2 h, 2.) 110 deg C, 18 h;

DOI:10.1055/s-1984-30719

Reference yield:

→ imipramine (303-54-8)

Guidance literature:

5H-Dibenzazepin, 3-Dimethylaminopropylchlorid, sd. Toluol, Ggw. von NaNH2, 17h;

DOI:10.1021/jo01060a032

upstream raw materials:

dibenzoazepine

3-(Dimethylamino)propyl chloride

formaldehyd

3-(5H-dibenzo[b,f]azepin-5-yl)propan-1-amine

Refernces

• 1、 Uliassi, Elisa,Pena-Altamira, Luis Emiliano,Morales, Aixa V.,Massenzio, Francesca,Petralla, Sabrina,Rossi, Michele,Roberti, Marinella,Martinez Gonzalez, Loreto,Martinez, Ana,Monti, Barbara,Bolognesi, Maria Laura. "A Focused Library of Psychotropic Analogues with Neuroprotective and Neuroregenerative Potential". . p. 279 - 294. Retrieved 2018/10/20.