BUTTPARK 41\09-78

Base Information

• Chemical Name: BUTTPARK 41\09-78
• CAS No.: 645401-61-2
• Molecular Formula: C12H13N3O2
• Molecular Weight: 231.25100
• Hs Code.: 2933599090
• Mol file: 645401-61-2.mol

Synonyms:2-Pyrimidinamine,4-(3,4-dimethoxyphenyl);BB_SC-9170;

Chemical Property of BUTTPARK 41\09-78

Chemical Property:

• Melting Point: 138-139 °C
• Boiling Point: 438.5±55.0 °C(Predicted)
• PKA: 3.82±0.10(Predicted)
• PSA: 70.99000
• Density: 1?+-.0.06 g/cm3(Predicted)
• LogP: 1.67310

Purity/Quality:

95+% ^*data from raw suppliers

4-(3,4-Dimethoxyphenyl)pyrimidin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BUTTPARK 41\09-78

There total 2 articles about BUTTPARK 41\09-78 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

(Z)-3-chloro-3-(3,4-dimethoxyphenyl)acrylaldehyde (1036272-02-2) + guanidine hydrochloride (50-01-1) → 4-(3,4-dimethoxyphenyl)pyrimidin-2-amine (645401-61-2)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; Reflux;

DOI:10.1002/ejoc.201700737

Reference yield:

1-(3,4-dimethoxyphenyl)ethanone (1131-62-0) → 4-(3,4-dimethoxyphenyl)pyrimidin-2-amine (645401-61-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trichlorophosphate / 0.17 h / 0 °C

1.2: 3 h / 60 °C

2.1: potassium carbonate / methanol / 20 °C / Reflux

With potassium carbonate; trichlorophosphate; In methanol; 1.1: |Vilsmeier-Haack Formylation / 1.2: |Vilsmeier-Haack Formylation;

DOI:10.1002/ejoc.201700737

upstream raw materials:

(Z)-3-chloro-3-(3,4-dimethoxyphenyl)acrylaldehyde

guanidine hydrochloride

1-(3,4-dimethoxyphenyl)ethanone

Refernces