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50-01-1 Usage

Definition

ChEBI: An aminocarboxamidine, the parent compound of the guanidines.

Uses

Guanidine has a good bacterial and fungicidal efficacy when used in low concentration and can also be used as disinfectant.

description

Guanidine hydrochloride is a strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant.It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
Guanidine Hydrochloride is the hydrochloride salt form of guanidine, a strong basic compound with parasympathomimetic activity. Guanidine hydrochloride enhances the release of acetylcholine following a nerve impulse and potentiates acetylcholine actions on muscarinic and nicotinic receptors. It also appears to slow the rates of depolarization and repolarization of muscle cell membranes.
Guanidine Hydrochloride is a powerful, chaotropic agent which is widely used for purification of proteins and nucleic acids. Guanidine Hydrochloride is useful for denaturation and refolding of proteins as well as in the recovery of periplasmic proteins and isolation of RNA. At higher concentrations, this strong denaturant has been reported to solubilize denatured insoluble proteins such as inclusion bodies. When utilized at lower concentrations, Guanidine Hydrochloride is noted to be useful in prompting the refolding of denatured proteins. Guanidine Hydrochloride is also been reported to allow return of enzymatic activity in protocols using Guanidine Hydrochloride as a first step. Guanidine Hydrochloride is an inhibitor of RNase.
Guanidine hydrochloride is used for purification of proteins and nucleic acids. It can be used as a medicine, organic synthesis intermediate and is used in dyes. It acts as an intermediate in the preparation of sulfadiazine, which is an important raw material for sulfamethyldiazine, sulfamethazine and folic acid. It is utilized in the synthesis of 2-amino-pyrimidine, 2-amino-6-methyl-pyrimidine and 2-amino-4,6-dimethyl-pyrimidine. Also used in RNA isolation to dissociate nucleoproteins and inhibit RNase.

Chemical Properties

White cryst. powder

Preparation

In Dicyanodiamide and ammonium (Ammonium chloride) as raw material, melt reaction at 170-230 ℃, guanidine hydrochloride obtained crude, refined products.

Protein Denaturation

Guanidine Hydrochloride (GdnHCl) is a better denaturant than urea.It should normally give higher and lower values for m and for Cm, respectively, but identical deltaG° values. Since m values in both denaturants can be predicted/estimated from the size of the protein (Myers et al., 1995) and delatG° should not change, yes it is possible-in principle-to predict Cm in one denaturant, knowing its value in the other.
but to have a general correlation co-efficient is almost impossible as every protein has unique folding. Though such co-relation may be found for a special protein fold, but what purpose it may serve apart from giving a tentative idea that GdnHCl or urea may be a better denaturant! If you are looking for even better denaturant than Gdn HCl then use GdnSCN, it is better and more effective.

Drug intermediates

Guanidine hydrochloride drug used primarily as an intermediate in the manufacture of sulfadiazine, an important raw material sulfamethyldiazine, sulfamethazine and folic acid.
Guanidine hydrochloride (or guanidine nitrate) and ethyl cyanoacetate reaction, cyclization of 2,4-diamino-6-hydroxy pyrimidine, folic acid for the synthesis of antianemic. Furthermore guanidine hydrochloride also used synthetic anti-static agent.

Purification Methods

Crystallise the hydrochloride from hot methanol by chilling to about -10o, with vigorous stirring. The fine crystals are filtered through fritted glass, washed with cold (-10o) methanol, dried at 50o under vacuum for 5hours. (The product is purer than that obtained by crystallisation at room temperature from methanol by adding large amounts of diethyl ether.) [Kolthoff et al. J Am Chem Soc 79 5102 1957, Beilstein 3 H 86, 3 II 71, 3 III 160, 3 IV 150.]

Uses

cholinergic

Reference quality standards

Name of Project Specifications
Pharmaceutical grade industrial grade
Appearance white crystal; white crystal
Content > 99% 99.5%
Ammonium <0.3% 0.5%
Water Insoluble substance <0.1% 0.1%
Moisture <0.3% 0.3%
Ash <0.05% 0.05%
Water-soluble test qualified; qualified
Melting range °C 184-188; 182-188
Absorbance (UV wavelength 260NM) <=0.04
Absorbance (UV wavelength 280NM) <=0.02
PH value (4% aqueous solution) 6.4 ± 0.2 6.4 ± 0.2

Uses

Used to synthesis medicine, pesticide, dye and other organic compound, is the important material to make sulfanilamide medicine and folacin, and can be used as anti-static agent of compound fibre.

Uses

Guanidine hydrochloride is used in RNA isolation to dissociate nucleoproteins and inhibit RNase.
Strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary.
InChI:InChI=1/CH5N3.ClH/c2-1(3)4;/h(H5,2,3,4);1H/p+1

50-01-1 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Alfa Aesar (M10020)  GUANIDINE HYDROCHLORIDE, ULTRA PURE, 99%    50-01-1 1kg 1826.0CNY Detail
Alfa Aesar (A13543)  Guanidine hydrochloride, 98%    50-01-1 5000g 1329.0CNY Detail
Alfa Aesar (A13543)  Guanidine hydrochloride, 98%    50-01-1 1000g 317.0CNY Detail
Alfa Aesar (A13543)  Guanidine hydrochloride, 98%    50-01-1 250g 138.0CNY Detail
TCI America (G0197)  Guanidine Hydrochloride [for Protein Research]  >99.0%(T) 50-01-1 500g 1,320.00CNY Detail
TCI America (G0197)  Guanidine Hydrochloride [for Protein Research]  >99.0%(T) 50-01-1 100g 590.00CNY Detail
TCI America (G0197)  Guanidine Hydrochloride [for Protein Research]  >99.0%(T) 50-01-1 25g 300.00CNY Detail

50-01-1Synthetic route

guanidinium trinitromethanide

guanidinium trinitromethanide

guanidine hydrochloride
50-01-1

guanidine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In diethyl ether at 0℃; Product distribution;78%
N1-methyl biguanide hydrochloride
1674-62-0

N1-methyl biguanide hydrochloride

A

CYANAMID
420-04-2

CYANAMID

B

1-methylguanidine
471-29-4

1-methylguanidine

C

guanidine hydrochloride
50-01-1

guanidine hydrochloride

D

methylcyanamide
4674-68-4

methylcyanamide

Conditions
ConditionsYield
bei der thermischen Zersetzung;
urea
57-13-6

urea

guanidine hydrochloride
50-01-1

guanidine hydrochloride

Conditions
ConditionsYield
With aluminium trichloride; ammonia at 300℃;
N-methylguanidine hydrochloride

N-methylguanidine hydrochloride

2-amino-4,5-dihydro-4,5-dihydroxyimidazolium chloride

2-amino-4,5-dihydro-4,5-dihydroxyimidazolium chloride

A

guanidine hydrochloride
50-01-1

guanidine hydrochloride

B

1-methyl-2-amino-4,5-dihydro-4,5-dihydroxyimidazolinium chloride

1-methyl-2-amino-4,5-dihydro-4,5-dihydroxyimidazolinium chloride

Conditions
ConditionsYield
In chloroform-d1 Equilibrium constant; pH 8;
N-Cyanoguanidine
127099-85-8, 780722-26-1

N-Cyanoguanidine

aqueous ammonium chloride

aqueous ammonium chloride

A

ammelide
645-93-2

ammelide

B

guanidine hydrochloride
50-01-1

guanidine hydrochloride

C

BIGUANIDE
56-03-1

BIGUANIDE

Conditions
ConditionsYield
at 150℃;
tetrachloromethane
56-23-5

tetrachloromethane

ammonia
7664-41-7

ammonia

iodine
7553-56-2

iodine

copper

copper

A

hydrogen cyanide
74-90-8

hydrogen cyanide

B

ethanedinitrile
460-19-5

ethanedinitrile

C

guanidine hydrochloride
50-01-1

guanidine hydrochloride

Conditions
ConditionsYield
at 140℃;
ethanol
64-17-5

ethanol

CYANAMID
420-04-2

CYANAMID

ammonium chloride

ammonium chloride

guanidine hydrochloride
50-01-1

guanidine hydrochloride

Conditions
ConditionsYield
at 100℃;
hydrogenchloride
7647-01-0

hydrogenchloride

tetranitromethane
509-14-8

tetranitromethane

nickel coated zinc

nickel coated zinc

A

ammonium chloride

ammonium chloride

B

guanidine hydrochloride
50-01-1

guanidine hydrochloride

ammonia
7664-41-7

ammonia

O-ethyl-isourea hydrochloride
31407-74-6

O-ethyl-isourea hydrochloride

guanidine hydrochloride
50-01-1

guanidine hydrochloride

thiocarbimidoic acid O-ethyl ester-S-methyl ester; hydrochloride

thiocarbimidoic acid O-ethyl ester-S-methyl ester; hydrochloride

concentrated alcoholic ammonia

concentrated alcoholic ammonia

guanidine hydrochloride
50-01-1

guanidine hydrochloride

ammonium chloride

ammonium chloride

urea
57-13-6

urea

guanidine hydrochloride
50-01-1

guanidine hydrochloride

Conditions
ConditionsYield
With silica gel In melt 160 until 230°C; 1.5-fold excess of NH4Cl; in the presence of the same amt. of silica gel as urea;
tetrachloromethane
56-23-5

tetrachloromethane

A

ammonium dicyanamide

ammonium dicyanamide

B

dicyandiamide
127099-85-8, 780722-26-1

dicyandiamide

C

hexachloroethane
67-72-1

hexachloroethane

D

ammonium chloride

ammonium chloride

E

guanidine hydrochloride
50-01-1

guanidine hydrochloride

Conditions
ConditionsYield
With ammonia In tetrachloromethane other Radiation; γ-radiation of NH3 soln. in CCl4 at 25°C; mechanism discussed; further products and further intermediates;;
ammonium chloride

ammonium chloride

guanidine hydrochloride
50-01-1

guanidine hydrochloride

aluminium trichloride
7446-70-0

aluminium trichloride

ammonia
7664-41-7

ammonia

urea
57-13-6

urea

guanidine hydrochloride
50-01-1

guanidine hydrochloride

Conditions
ConditionsYield
300°C; in autoclave;
300°C; in autoclave;
tetrachloromethane
56-23-5

tetrachloromethane

ammonia
7664-41-7

ammonia

guanidine hydrochloride
50-01-1

guanidine hydrochloride

Conditions
ConditionsYield
With iodine; copper byproducts: HCN, cyanogen; High Pressure; 140°C; 17 h;35-40
With Cu; I2
ammonium bicarbonate
1066-33-7

ammonium bicarbonate

guanidine hydrochloride
50-01-1

guanidine hydrochloride

diguanidine carbonate
593-85-1

diguanidine carbonate

guanidine hydrochloride
50-01-1

guanidine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride
guanidine carbonate
593-85-1

guanidine carbonate

guanidine hydrochloride
50-01-1

guanidine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In water for 4h;
guanidine hydrochloride
50-01-1

guanidine hydrochloride

3-methylthio-1-phenyl-4-phenylsulfonyl-2-buten-1-one
94012-44-9, 94012-45-0

3-methylthio-1-phenyl-4-phenylsulfonyl-2-buten-1-one

2-amino-4-phenyl-6-(phenylsulphonyl-methyl)pyrimidine
106808-11-1

2-amino-4-phenyl-6-(phenylsulphonyl-methyl)pyrimidine

Conditions
ConditionsYield
With sodium In ethanol for 2h; Heating;100%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

guanidine hydrochloride
50-01-1

guanidine hydrochloride

tert-butyl N-(diaminomethylidene)carbamate
219511-71-4

tert-butyl N-(diaminomethylidene)carbamate

Conditions
ConditionsYield
Stage #1: guanidine hydrochloride With sodium hydroxide In water at 0℃; for 0.166667h; Inert atmosphere;
Stage #2: di-tert-butyl dicarbonate In water; acetone at 0 - 20℃; for 2.5h; Inert atmosphere;
100%
With sodium hydroxide In 1,4-dioxane for 15h;88%
With sodium hydroxide In 1,4-dioxane; water at 0 - 20℃;66%
guanidine hydrochloride
50-01-1

guanidine hydrochloride

4-(Cyclohexyloxy)acetessigsaeure-ethylester
126930-22-1

4-(Cyclohexyloxy)acetessigsaeure-ethylester

2-amino-6-(cyclohexyloxymethyl)pyrimidin-4-ol
1161825-17-7

2-amino-6-(cyclohexyloxymethyl)pyrimidin-4-ol

Conditions
ConditionsYield
With sodium methylate In ethanol Heating / reflux;100%
guanidine hydrochloride
50-01-1

guanidine hydrochloride

N,N',N''-triaminoguanidine
2203-24-9

N,N',N''-triaminoguanidine

Conditions
ConditionsYield
With hydrazine hydrate In 1,4-dioxane for 2h; Reflux;100%
With hydrazine hydrate In 1,4-dioxane for 2h; Reflux; Inert atmosphere;100%
With hydrazine hydrate In 1,4-dioxane for 2h; Reflux;98%
guanidine hydrochloride
50-01-1

guanidine hydrochloride

ethylenediamine
107-15-3

ethylenediamine

2-amino-2-imidazoline
19437-45-7

2-amino-2-imidazoline

Conditions
ConditionsYield
In neat (no solvent) for 16h; Solvent; Reagent/catalyst; Inert atmosphere; Reflux;100%
2-chloro-10-(3-chloropropyl)-10H-phenothiazine
2765-59-5

2-chloro-10-(3-chloropropyl)-10H-phenothiazine

guanidine hydrochloride
50-01-1

guanidine hydrochloride

[3-(2-chloro-phenothiazin-10-yl)-propyl]-guanidine
2518-14-1

[3-(2-chloro-phenothiazin-10-yl)-propyl]-guanidine

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water at 80℃; for 72h;100%
guanidine hydrochloride
50-01-1

guanidine hydrochloride

guanidinium hydroiodide
19227-70-4

guanidinium hydroiodide

Conditions
ConditionsYield
With sodium iodide In methanol; acetone for 12h; Reflux;100%
guanidine hydrochloride
50-01-1

guanidine hydrochloride

C20H23N5O2

C20H23N5O2

C15H21N7O2

C15H21N7O2

Conditions
ConditionsYield
With sodium methylate In ethanol at 90℃; for 16h;100%
guanidine hydrochloride
50-01-1

guanidine hydrochloride

guanidinium dinitramide

guanidinium dinitramide

Conditions
ConditionsYield
With silver(I) dinitramide In methanol99%
With dinitramide potassium salt In water at 20℃; for 0.5h; Green chemistry;3.3 g
guanidine hydrochloride
50-01-1

guanidine hydrochloride

5-amino-1-benzyl-1H-imidazole-4-carbonitrile
60598-48-3

5-amino-1-benzyl-1H-imidazole-4-carbonitrile

2,6-diamino-9-benzylpurine
7674-36-4

2,6-diamino-9-benzylpurine

Conditions
ConditionsYield
In ethanol for 10h; Heating;99%
di-p-tolylbutadiyne
22666-07-5

di-p-tolylbutadiyne

guanidine hydrochloride
50-01-1

guanidine hydrochloride

(2-amino-6-(p-tolyl)pyrimidin-4-yl)(p-tolyl)methanone

(2-amino-6-(p-tolyl)pyrimidin-4-yl)(p-tolyl)methanone

Conditions
ConditionsYield
With caesium carbonate; dimethyl sulfoxide at 120℃; for 12h; Sealed tube; Schlenk technique; regioselective reaction;99%
1,4-diphenyl-1,3-butadiyne
886-66-8

1,4-diphenyl-1,3-butadiyne

guanidine hydrochloride
50-01-1

guanidine hydrochloride

(2-amino-6-phenyl-pyrimidin-4-yl)(phenyl)methanone

(2-amino-6-phenyl-pyrimidin-4-yl)(phenyl)methanone

Conditions
ConditionsYield
With caesium carbonate; dimethyl sulfoxide at 120℃; for 12h; Reagent/catalyst; Temperature; Sealed tube; Schlenk technique; regioselective reaction;99%
With caesium carbonate In dimethyl sulfoxide at 120℃; Reagent/catalyst; Sealed tube;99%
1,4-bis(3-methylphenyl)-1,3-butadiyne

1,4-bis(3-methylphenyl)-1,3-butadiyne

guanidine hydrochloride
50-01-1

guanidine hydrochloride

(2-amino-6-(m-tolyl)pyrimidin-4-yl)(m-tolyl)methanone

(2-amino-6-(m-tolyl)pyrimidin-4-yl)(m-tolyl)methanone

Conditions
ConditionsYield
With caesium carbonate; dimethyl sulfoxide at 120℃; for 12h; Sealed tube; Schlenk technique; regioselective reaction;99%
1,4-diphenyl-1,3-butadiyne
886-66-8

1,4-diphenyl-1,3-butadiyne

guanidine hydrochloride
50-01-1

guanidine hydrochloride

4-benzyl-6-phenylpyrimidin-2-amine

4-benzyl-6-phenylpyrimidin-2-amine

Conditions
ConditionsYield
With caesium carbonate In dimethyl sulfoxide at 120℃; Temperature; Sealed tube;99%
formaldehyd
50-00-0

formaldehyd

guanidine hydrochloride
50-01-1

guanidine hydrochloride

methylamine
74-89-5

methylamine

2,5,8-trimethyl-2,3,5,6,8,9-hexahydro-1H,4H,7H-2,5,6a,8,9a-pentaaza-3a-azoniaphenalene chloride

2,5,8-trimethyl-2,3,5,6,8,9-hexahydro-1H,4H,7H-2,5,6a,8,9a-pentaaza-3a-azoniaphenalene chloride

Conditions
ConditionsYield
In ethanol; water at 5 - 20℃; for 72h;99%
guanidine hydrochloride
50-01-1

guanidine hydrochloride

3-dimethylamino-1-(3-nitrophenyl)-2-propen-1-one

3-dimethylamino-1-(3-nitrophenyl)-2-propen-1-one

4-(3-nitrophenyl)-2-aminopyrimidine

4-(3-nitrophenyl)-2-aminopyrimidine

Conditions
ConditionsYield
Stage #1: guanidine hydrochloride With potassium carbonate In ethanol at 20℃; for 0.666667h;
Stage #2: 3-dimethylamino-1-(3-nitrophenyl)-2-propen-1-one In ethanol at 80℃; for 20h;
98.7%
guanidine hydrochloride
50-01-1

guanidine hydrochloride

N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine
112-57-2

N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

tridecanoic acid
638-53-9

tridecanoic acid

C37H77N11O2*ClH

C37H77N11O2*ClH

Conditions
ConditionsYield
Stage #1: N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine; tridecanoic acid With toluene-4-sulfonic acid at 155℃; for 2.75h;
Stage #2: guanidine hydrochloride at 152 - 176℃; for 5h;
98.5%
C22H19Cl3O6S

C22H19Cl3O6S

guanidine hydrochloride
50-01-1

guanidine hydrochloride

3,4-dichlorophenyl 3-O-[(2-amino-(4-chlorophenyl)pyrimidin-6-yl)methylene]-1-thio-α-D-galactopyranoside

3,4-dichlorophenyl 3-O-[(2-amino-(4-chlorophenyl)pyrimidin-6-yl)methylene]-1-thio-α-D-galactopyranoside

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran Inert atmosphere; Reflux;98.5%
guanidine hydrochloride
50-01-1

guanidine hydrochloride

(Z)-2-(4-Butoxy-3-methoxy-benzyl)-3-phenylamino-acrylonitrile

(Z)-2-(4-Butoxy-3-methoxy-benzyl)-3-phenylamino-acrylonitrile

5-(4-butoxy-3-methoxy-benzyl)-pyrimidine-2,4-diamine
80267-19-2

5-(4-butoxy-3-methoxy-benzyl)-pyrimidine-2,4-diamine

Conditions
ConditionsYield
With sodium methylate In ethanol for 24h; Heating;98%
guanidine hydrochloride
50-01-1

guanidine hydrochloride

triaminoguanidine hydrochloride
5329-29-3

triaminoguanidine hydrochloride

Conditions
ConditionsYield
With hydrazine hydrate In 1,4-dioxane for 2h; Heating;98%
With hydrazine hydrate In 1,4-dioxane for 2h; Reflux;98%
With hydrazine hydrate In isopropyl alcohol for 6h; Reflux;97%
guanidine hydrochloride
50-01-1

guanidine hydrochloride

5-bromo-4-nitro-1-(2'-deoxy-β-D-ribofuranosyl)imidazole
657408-23-6

5-bromo-4-nitro-1-(2'-deoxy-β-D-ribofuranosyl)imidazole

5-guanidino-4-nitro-1-(2'-deoxy-β-D-ribofuranosyl)imidazole

5-guanidino-4-nitro-1-(2'-deoxy-β-D-ribofuranosyl)imidazole

Conditions
ConditionsYield
Stage #1: guanidine hydrochloride With sodium methylate In methanol
Stage #2: 5-bromo-4-nitro-1-(2'-deoxy-β-D-ribofuranosyl)imidazole In ethanol for 2h; Heating;
98%
1-[3-(4-chlorophenyl)-benzo[c]isoxazole-5-yl]-3-dimethylamino-propenone

1-[3-(4-chlorophenyl)-benzo[c]isoxazole-5-yl]-3-dimethylamino-propenone

guanidine hydrochloride
50-01-1

guanidine hydrochloride

4-(3-(4-chlorophenyl)benzo[c]isoxazol-5-yl)pyrimidin-2-amine
477845-12-8

4-(3-(4-chlorophenyl)benzo[c]isoxazol-5-yl)pyrimidin-2-amine

Conditions
ConditionsYield
With sodium In methanol at 20 - 80℃; for 18h;98%
guanidine hydrochloride
50-01-1

guanidine hydrochloride

hydrazine hydrate
7803-57-8

hydrazine hydrate

triaminoguanidine hydrochloride
5329-29-3

triaminoguanidine hydrochloride

Conditions
ConditionsYield
In 1,4-dioxane for 2h; Reflux;98%
1,1,3,6,8,8-Hexanitro-3,6-diaza-octan
41792-58-9

1,1,3,6,8,8-Hexanitro-3,6-diaza-octan

guanidine hydrochloride
50-01-1

guanidine hydrochloride

bis(2,2-dinitroethanide-N-nitro)ethylenediamine bis(guanidium) salt

bis(2,2-dinitroethanide-N-nitro)ethylenediamine bis(guanidium) salt

Conditions
ConditionsYield
Stage #1: guanidine hydrochloride With sodium hydroxide In methanol at 20℃; for 0.166667h;
Stage #2: 1,1,3,6,8,8-Hexanitro-3,6-diaza-octan In acetonitrile at 20℃; for 1h;
98%
1,4-bis(4-n-pentylphenyl)buta-1,3-diyne

1,4-bis(4-n-pentylphenyl)buta-1,3-diyne

guanidine hydrochloride
50-01-1

guanidine hydrochloride

(2-amino-6-(4-pentylphenyl)pyrimidin-4-yl)(4-pentylphenyl)methanone

(2-amino-6-(4-pentylphenyl)pyrimidin-4-yl)(4-pentylphenyl)methanone

Conditions
ConditionsYield
With caesium carbonate; dimethyl sulfoxide at 120℃; for 12h; Sealed tube; Schlenk technique; regioselective reaction;98%
1'-naphthacetophenone
941-98-0

1'-naphthacetophenone

guanidine hydrochloride
50-01-1

guanidine hydrochloride

9-anthracene aldehyde
642-31-9

9-anthracene aldehyde

4-(anthracen-9-yl)-6-(naphthalen-1-yl)-1,6-dihydropyrimidine-2-amine

4-(anthracen-9-yl)-6-(naphthalen-1-yl)-1,6-dihydropyrimidine-2-amine

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 50 - 60℃; Sonication; Green chemistry;98%
3-chloro-2-methylpent-2-enal
1679-39-6

3-chloro-2-methylpent-2-enal

guanidine hydrochloride
50-01-1

guanidine hydrochloride

4-ethyl-5-methylpyrimidin-2-amine
35733-54-1

4-ethyl-5-methylpyrimidin-2-amine

Conditions
ConditionsYield
With potassium carbonate In methanol Reflux;98%
(E)-3-dimethylamino-1-(4-nitrophenyl)-2-propen-1-one
78089-99-3

(E)-3-dimethylamino-1-(4-nitrophenyl)-2-propen-1-one

guanidine hydrochloride
50-01-1

guanidine hydrochloride

2-amino-4-(p-nitrophenyl)pyrimidine
99361-84-9

2-amino-4-(p-nitrophenyl)pyrimidine

Conditions
ConditionsYield
Stage #1: guanidine hydrochloride With potassium carbonate In ethanol at 20℃; for 0.666667h;
Stage #2: (E)-3-dimethylamino-1-(4-nitrophenyl)-2-propen-1-one In ethanol at 80℃; for 20h;
97.3%
Stage #1: guanidine hydrochloride With sodium hydroxide In ethanol for 0.5h;
Stage #2: (E)-3-dimethylamino-1-(4-nitrophenyl)-2-propen-1-one In ethanol at 40℃; for 12h;
57%
(E)-3-(dimethylamino)-1-(6-(3-nitrophenyl)-2,3-dihydroimidazo[2,1-b]thiazol-5-yl)prop-2-en-1-one

(E)-3-(dimethylamino)-1-(6-(3-nitrophenyl)-2,3-dihydroimidazo[2,1-b]thiazol-5-yl)prop-2-en-1-one

guanidine hydrochloride
50-01-1

guanidine hydrochloride

4-(6-(3-nitrophenyl)-2,3-dihydroimidazo[2,1-b]thiazol-5-yl)pyrimidin-2-amine

4-(6-(3-nitrophenyl)-2,3-dihydroimidazo[2,1-b]thiazol-5-yl)pyrimidin-2-amine

Conditions
ConditionsYield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 120℃;97.2%
guanidine hydrochloride
50-01-1

guanidine hydrochloride

tert-butyl 4-<5,5-dicyano-4-(dimethoxymethyl)pentyl>benzoate
134373-03-8

tert-butyl 4-<5,5-dicyano-4-(dimethoxymethyl)pentyl>benzoate

tert-butyl 4-<4-(2,4,6-triaminopyrimidin-5-yl)-5,5-dimethoxypentyl>benzoate
134373-08-3

tert-butyl 4-<4-(2,4,6-triaminopyrimidin-5-yl)-5,5-dimethoxypentyl>benzoate

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran; tert-butyl alcohol for 2h; Heating;97%

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